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Increased Th17 and Th22 Cell Percentages Predict Acute Lung Injury in Patients with Sepsis

  • ACUTE LUNG INJURY
  • Published:
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Abstract

Purpose

This study was conducted to investigate the percentages of Th22 and Th17 cells in the peripheral blood of septic patients with and without acute lung injury (ALI) and their clinical significance.

Methods

A total of 479 patients were divided into non-ALI and ALI groups. The percentages of Th22 and Th17 cells and the levels of interleukin 22 (IL-22), 6 (IL-6), and 17 (IL-17) were determined. Receiver operating characteristic curve analysis was performed to assess the diagnostic value of Th22 and Th17 cells to predict sepsis-induced ALI.

Results

The lung injury prediction score (LIPS), IL-6, IL-17, and IL-22 levels and the percentages of Th17 and Th22 cells were significantly higher in the ALI group (P < 0.05). They were significant factors affecting sepsis-induced ALI (P < 0.05). Multivariate logistic regression analysis showed that the LIPS (OR = 1.130), IL-17 (OR = 1.982), IL-22 (OR = 2.612) and the percentages of Th17 (OR = 2.211) and Th22 (OR = 3.230) cells were independent risk factors for ALI. The area under the curve of Th22 cells was 0.844 to predict ALI with a cutoff value of 6.81%. The sensitivity and specificity for early diagnosis of sepsis-induced ALI by the Th22 cell percentage were 78.72% and 89.13%, respectively.

Conclusions

Th22 and Th17 cells in peripheral blood are significantly increased in septic patients with ALI and they may be used as biomarkers for early diagnosis of sepsis-induced ALI.

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Data Availability

The datasets used during the current study are available from the corresponding author on reasonable request.

Abbreviations

AUC:

Area under curve

ALI:

Acute lung injury

IL:

Interleukin

ROC:

Receiver operating characteristic curve

LIPS:

Lung injury prediction score

TNF-α:

Tumor necrosis factor α

PCT:

Procalcitonin

CRP:

C reactive protein

IQR:

Interquartile range

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Funding

This study was supported by Medical Health Science and Technology Projects, Zhejiang Provincial Health Commission, Zhejiang, China (Grant Nos. 2016–33 and 2020KY441).

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Authors and Affiliations

  1. Department of Emergency Medicine, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 310014, China

    Gang Li, Nannan Han, Ke Zhang & Hengjie Li

  2. Department of Critical Care Medicine, Chunan First People’s Hospital, Zhejiang Provincial People’s Hospital Chunan Branch, Chunan, China

    Liangtian Zhang

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  1. Gang Li
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  2. Liangtian Zhang
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  4. Ke Zhang
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Contributions

GL and LZ designed the study. LZ, NH and KZ collected the data and performed analysis. GL, LZ and HL drafted the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Gang Li.

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Conflict of interest

The authors declare that they have no competing interests.

Ethics Approval

This study was approved by the ethical committee of Zhejiang Provincial People's Hospital.

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Written informed consent was obtained from every patient.

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Cite this article

Li, G., Zhang, L., Han, N. et al. Increased Th17 and Th22 Cell Percentages Predict Acute Lung Injury in Patients with Sepsis. Lung 198, 687–693 (2020). https://doi.org/10.1007/s00408-020-00362-1

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  • DOI: https://doi.org/10.1007/s00408-020-00362-1

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