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Prevalence of affective disorders and dementia in inflammatory polyarthropathies

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Abstract

Comorbid disorders are common in psychiatric diseases and understanding the risk of secondary diseases can aid successful clinical treatment. The objective of this study was to compare the frequency of comorbid dementia, affective disorders, and inflammatory polyarthropathies. Healthcare data obtained via the German Hospital Fees Act from two independent databases with more than 7.4 million cases were analyzed to compare the prevalence of comorbid disorders. Comorbid inflammatory polyarthropathy was observed in 2.27% of patients diagnosed with affective disorders and 1.35% of patients with dementia (p < 0.001). Among patients with a primary diagnosis of inflammatory polyarthropathy, 1.27% of patients were diagnosed with dementia, whereas 4.55% of age-matched patients without inflammatory polyarthropathies had comorbid dementia (p < 0.001). The opposite effect was demonstrated for affective disorders, as 5.77% of patients with a primary diagnosis of inflammatory polyarthropathy also had comorbid affective disorders, while 4.87% of age-matched patients without inflammatory polyarthropathy had an accompanying affective disease (p < 0.001). These findings show an association between the occurrence of inflammatory polyarthropathies, dementia, and affective disorders. This correlation might improve diagnosis and treatment for patients with comorbidities. Moreover, further exploration of the molecular pathophysiology underlying these relationships could be relevant for the development of novel treatment options.

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Acknowledgements

We would like to thank Editage (https://www.editage.com) for English language editing. Prof. Jens Wiltfang is supported by an Ilídio Pinho professorship and iBiMED (UID/BIM/04501/2013), and FCT project PTDC/DTP_PIC/5587/2014 at the University of Aveiro, Portugal. Stephan Gyßer is full-time employee of GSG consultant.

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany

    Jonathan Vogelgsang, Philipp Heßmann, Claus Wolff-Menzler & Jens Wiltfang

  2. Division of Software Development and Business Intelligence, GSG Consulting GmbH, Flughafenring 2, 44319, Dortmund, Germany

    Stephan Gyßer

  3. Department of Nephrology and Rheumatology, University Medical Center Goettingen (UMG), Georg-August-University, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    Gerhard A. Müller

  4. German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany

    Jens Wiltfang

  5. iBiMED, Medical Science Department, University of Aveiro, Aveiro, Portugal

    Jens Wiltfang

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  1. Jonathan Vogelgsang
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Correspondence to Jens Wiltfang.

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SG is a full-time employee of GSG consultant. The remaining authors declare that they have no conflict of interest.

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Vogelgsang, J., Heßmann, P., Wolff-Menzler, C. et al. Prevalence of affective disorders and dementia in inflammatory polyarthropathies. Eur Arch Psychiatry Clin Neurosci 270, 247–252 (2020). https://doi.org/10.1007/s00406-019-01015-y

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  • DOI: https://doi.org/10.1007/s00406-019-01015-y

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