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Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task

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Abstract

The analysis of the interaction between novelty and relevance may be of interest to test the aberrant salience hypothesis of schizophrenia (SCH). In comparison with other neuroimaging techniques, such as functional magnetic resonance imaging, electroencephalography (EEG) provides high temporal resolution. Therefore, EEG is useful to analyze transient dynamics in neural activity, even in the range of milliseconds. In this study, EEG activity from 31 patients with SCH and 38 controls was analyzed using Shannon spectral entropy (SE) and median frequency (MF). The aim of the study was to quantify differences between distractor (i.e., novelty) and target (i.e., novelty and relevance) tones in an auditory oddball paradigm. Healthy controls displayed a larger SE decrease in response to target stimulus than in response to distractor tones. SE decrease was accompanied by a significant and widespread reduction of MF (i.e., a significant slowing of EEG activity). In comparison with controls, patients showed a significant reduction of changes in SE in response to both target and distractor tones. These differences were also observed in patients that only received a minimal treatment prior to EEG recording. Furthermore, significant changes in SE were inversely correlated to positive and total symptoms severity for SCH patients. Our findings support the notion that SCH is associated with a reduced response to both novelty and relevance during an auditory P300 task.

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Acknowledgments

The present work was supported in part by: ‘Ministerio de Economía y Competitividad’ and FEDER under project TEC2011-22987 and by the ‘Project Cero 2011 on Ageing’ from ‘Fundación General CSIC,’ ‘Obra Social La Caixa’ and CSIC; ‘Fondo de Investigaciones Sanitarias (Instituto de Salud Carlos III)’ (FIS PI1102203) and the ‘Gerencia Regional de Salud de Castilla y León’ (GRS 613/A/11) Grants; a Marie Curie Intra European Fellowship within the 7th European Community Framework Programme (330156-CODIP) to A. Díez; a predoctoral scholarship from the University of Salamanca and Santander Bank to V. Suazo; and a PIF-UVA grant from the University of Valladolid to A. Bachiller.

Conflict of interest

All authors have approved the final manuscript. On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standard

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

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Authors and Affiliations

  1. Biomedical Engineering Group, Department T.S.C.I.T., E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Paseo Belén, 15, CP 47011, Valladolid, Spain

    Alejandro Bachiller, Alba Lubeiro, Roberto Hornero & Jesús Poza

  2. Division of Psychiatry, Faculty of Brain Sciences, University College London, Charles Bell House, 67-73 Riding House Street, London, W1W 7EJ, UK

    Álvaro Díez

  3. Neuroscience Institute of Castilla y León, University of Salamanca, Calle Pintor Fernando Gallego, 1, CP 37007, Salamanca, Spain

    Vanessa Suazo

  4. Institute of Biomedical Research (IBSAL), Salamanca, Spain

    Vanessa Suazo, Roberto Hornero, Jesús Poza & Vicente Molina

  5. Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain

    Cristina Domínguez, José A. Blanco & Vicente Molina

  6. Neurophysiology Service, University Hospital of Valladolid, Valladolid, Spain

    Marta Ayuso

  7. Instituto de Investigación en Matemáticas (IMUVA), University of Valladolid, Valladolid, Spain

    Roberto Hornero & Jesús Poza

  8. Psychiatry Department, Faculty of Medicine, University of Valladolid, Avenida de Ramón y Cajal, 7, CP 47005, Valladolid, Spain

    Vicente Molina

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  1. Alejandro Bachiller
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  2. Alba Lubeiro
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  4. Vanessa Suazo
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  5. Cristina Domínguez
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  6. José A. Blanco
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  10. Vicente Molina
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Correspondence to Vicente Molina.

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Bachiller, A., Lubeiro, A., Díez, Á. et al. Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task. Eur Arch Psychiatry Clin Neurosci 265, 525–535 (2015). https://doi.org/10.1007/s00406-014-0525-5

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  • DOI: https://doi.org/10.1007/s00406-014-0525-5

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