Abstract
Purpose
Cervical lymph node metastasis is a prognostic factor of papillary thyroid carcinoma (PTC). This study aimed to investigate clinicopathological features and risk factors of skip lateral lymph node metastasis in PTC patients.
Methods
We retrospectively reviewed medical records of patients who underwent simultaneous total thyroidectomy with therapeutic central compartment lymph node dissection (LND) and lateral LND for primary PTC from 2014 to 2019. Univariate and multivariate logistic regression analyses were performed to identify clinicopathologic risk factors for skip metastasis. Receiver-operating characteristic (ROC) curves were constructed using the results of the multiple logistic regression analysis to identify data points with the highest sensitivity and lowest false-negative rate.
Results
The frequency of skip metastasis was approximately 12.8% (50/390). Multivariate logistic regression analysis showed that age (odds ratio [OR], 1.033; 95% confidence interval [CI], 1.008–1.059; P = 0.010), tumor size (OR 0.251; 95% CI 0.129–0.490; P < 0.001) and tumor located in the upper portion (OR 0.378; 95% CI 0.200–0.715; P = 0.003) were independent risk factors of skip metastasis (all P < 0.05). The ROC curves showed that the cut-off value of age for predicting skip metastasis was 44.5 years old (sensitivity = 0.620, specificity = 0.618, area under the curve [AUC] = 0.627, P = 0.004); the cut-off value of the tumor diameter for predicting skip metastasis was 1.05 cm (sensitivity = 0.503, specificity = 0.760, AUC = 0.682, P < 0.001).
Conclusions
Skip metastasis was common in PTC. The PTC patients with age > 44.5 years, tumor diameter < 1.05 cm and tumor located in the upper portion should be carefully evaluated for skip metastasis.
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References
Arboleda LPA, de Mendonça RMH, Lopez EEM, Araújo ALD, Palmier NR, de Pauli PM et al (2020) Global frequency and distribution of head and neck cancer in pediatrics, a systematic review. Crit Rev Oncol Hemat 148:102892
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE et al (2016) 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26:1–133
Siegel RL, Miller KD, Jemal A (2018) Cancer statistics. Cancer J Clin 68:7–30
Or K, Benbassat C, Koren S, Shteinshneider M, Koren R, Cantrell D et al (2018) Adherence to ATA 2015 guidelines in the management of unifocal non-invasive papillary thyroid cancer: a clinical survey among endocrinologists and surgeons. Eur Arch Otorhinolaryngol 275:2851–2859
Zhan S, Luo D, Ge W, Zhang B, Wang T (2019) Clinicopathological predictors of occult lateral neck lymph node metastasis in papillary thyroid cancer: a meta-analysis. Head Neck 41:2441–2449
Zhao H, Li H (2019) Meta-analysis of ultrasound for cervical lymph nodes in papillary thyroid cancer: diagnosis of central and lateral compartment nodal metastases. Eur J Radiol 112:14–21
Jin SH, Kim IS, Ji YB, Song CM, Chung MS, Tae K (2020) Efficacy of prophylactic central neck dissection in hemithyroidectomy for papillary thyroid carcinoma. Eur Arch Otorhinolaryngol 277:873–879
Dong W, Horiuchi K, Tokumitsu H, Sakamoto A, Noguchi E, Ueda Y et al (2019) Time-varying pattern of mortality and recurrence from papillary thyroid cancer: lessons from a long-term follow-up. Thyroid 29:802–808
Kim SH, Roh JL, Gong G, Cho KJ, Choi SH, Nam SY et al (2016) Differences in the recurrence and survival of patients with symptomatic and asymptomatic papillary thyroid carcinoma: an observational study of 11,265 person-years of follow-up. Thyroid 26:1472–1479
Molteni G, Bonali M, Mattioli F, Ghirelli M, Fermi M, Ferri G et al (2019) Central compartment revision surgery for persistent or recurrent thyroid carcinoma: analysis of survival and complication rate. Eur Arch Otorhinolaryngol 276:551–557
Likhterov I, Reis LL, Urken ML (2017) Central compartment management in patients with papillary thyroid cancer presenting with metastatic disease to the lateral neck: anatomic pathways of lymphatic spread. Head Neck 39:853–859
Lei J, Zhong J, Jiang K, Li Z, Gong R, Zhu J (2017) Skip lateral lymph node metastasis leaping over the central neck compartment in papillary thyroid carcinoma. Oncotarget 8:27022–27033
Lee YS, Shin SC, Lim YS, Lee JC, Wang SG, Son SM et al (2014) Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer. Head Neck 36:887–891
Kuvezdić KG, Aurer I, Ries S, Sucić M, Glamocak MM, Ilić I et al (2010) FNA based diagnosis of head and neck nodal lymphoma. Coll Antropol 34:7–12
Feng JW, Qin AC, Ye J, Pan H, Jiang Y, Qu Z (2020) Predictive factors for lateral lymph node metastasis and skip metastasis in papillary thyroid carcinoma. Endocr Pathol 31:67–76
Jin WX, Jin YX, Ye DR, Zheng ZC, Sun YH, Zhou XF et al (2018) Predictive factors of skip metastasis in papillary thyroid cancer. Med Sci Monit 24:2744–2749
Hu D, Lin H, Zeng X, Wang T, Deng J, Su X (2020) Risk factors for and prediction model of skip metastasis to lateral lymph nodes in papillary thyroid carcinoma. World J Surg 44:1498–1505
Zhao H, Huang T, Li H (2019) Risk factors for skip metastasis and lateral lymph node metastasis of papillary thyroid cancer. Surgery 166:55–60
Zhao W, Chen S, Hou X, Liao Q, Chen G, Zhao Y (2019) Predictive factors of lateral lymph node metastasis in papillary thyroid microcarcinoma. Pathol Oncol Res 25:1245–1251
Özden S, Çomçalı B, Ataş H, Er S, Tez M, Saylam B (2020) A diagnostic dilemma: skip metastasis in papillary thyroid cancer. Am Surg 86:245–249
Koo BS, Choi EC, Park YH, Kim EH, Lim YC (2010) Occult contralateral central lymph node metastases in papillary thyroid carcinoma with unilateral lymph node metastasis in the lateral neck. J Am Coll Surg 210:895–900
Lim YC, Koo BS (2012) Predictive factors of skip metastases to lateral neck compartment leaping central neck compartment in papillary thyroid carcinoma. Oral Oncol 48:262–265
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This work was supported by the National Natural Science Foundation of China (Grant Number 81972543).
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Hou, J., Zhang, Y., Fan, Y. et al. Risk factors of skip lateral lymph node metastasis in papillary thyroid carcinoma. Eur Arch Otorhinolaryngol 278, 493–498 (2021). https://doi.org/10.1007/s00405-020-06176-4
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DOI: https://doi.org/10.1007/s00405-020-06176-4