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Non-epithelial tumors of the larynx: case series of 12 years

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Laryngeal neoplasms are almost always epithelial in origin and squamous cell carcinoma is the most common tumor of the larynx. Non-epithelial tumors make a small subset of laryngeal neoplasms. We present the experience of a single institution to define clinical presentations and outcomes.

Materials and methods

The pathology archives and clinical records of our center with the diagnosis of laryngeal tumors between the 2005 and 2018 were reviewed. Age, gender, symptoms, location of the tumor, histopathological diagnosis, treatment modality and disease status were discussed.

Results

657 patients were diagnosed with laryngeal tumor between 2005 and 2018 and 13 patients with non-epithelial tumors were identified. The majority of the patients were male. The age ranged between 13 and 93 years. The most common tumor localizations were vocal cords and subglottis. Seven patients were diagnosed with malignant tumors and six patients had benign tumors. Chondrosarcoma was the most common malignant mesenchymal tumor. Others were leiomyosarcoma, fibrosarcoma and liposarcoma. The most common benign non-epithelial tumors were schwannoma and hemangioma. Plexiform neurofibroma and granular cell tumor were the other benign tumors. Eleven patients underwent excisional biopsy. One patient underwent partial laryngectomy and one had total laryngectomy. Three cases presented with recurrent tumor. Among the recurrent cases, two were malignant tumors.

Conclusion

Non-epithelial tumors of the larynx are rare and have a wide histological diversity. Immunohistochemical studies are of great importance in the diagnosis of these tumors. Primary mesenchymal tumors of the larynx should be kept in mind in differential diagnosis.

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Authors and Affiliations

  1. Department of Surgical Pathology, Faculty of Medicine, Uludag University, 16059, Gorukle, Bursa, Turkey

    Ozlem Saraydaroglu & Selin Narter

  2. Department of Surgical Pathology, Erzurum Regional Training and Research Hospital, 25240, Yakutiye, Erzurum, Turkey

    Mine Ozsen

  3. Department of Otorhinolaryngology, Faculty of Medicine, Uludag University, 16059, Gorukle, Bursa, Turkey

    Hakan Coskun

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  1. Ozlem Saraydaroglu
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Correspondence to Ozlem Saraydaroglu.

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Saraydaroglu, O., Narter, S., Ozsen, M. et al. Non-epithelial tumors of the larynx: case series of 12 years. Eur Arch Otorhinolaryngol 276, 2843–2847 (2019). https://doi.org/10.1007/s00405-019-05527-0

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  • DOI: https://doi.org/10.1007/s00405-019-05527-0

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