Abstract
Anaplastic carcinoma of the thyroid gland (ATC) is one of the most aggressive cancers in humans. With insufficient treatment, the disease most often leads to death in suffocation. From 2002, our treatment strategy has been hyperfractionated accelerated radiotherapy (HART) with high doses (64 Gy) to the neck, followed by surgery 4–8 weeks later if feasible, with the aim to gain control in the neck. After a pathology review, 51 patients were diagnosed with ATC in the period 2002–2014 in the south-east of Norway. Thirty-one received HART, and we present a study of these patients, with death in suffocation as the primary endpoint and survival as the second. No patients treated with HART died in suffocation. Six had a tracheostomy during their course of disease, of whom four were dependent on a tracheal cannula when they died. The best median survival, 19 months, was obtained in the 13 patients where both radiotherapy and surgery were possible as primary treatments. Only surgery came out as a prognostic factor for survival in multivariate analysis. Patients surviving more than 2 years were characterised by having surgery with R0 resection and no or small residual foci of ATC in the specimens. Stage 4C patients survived 3 months only.
Similar content being viewed by others
References
Bisof V, Rakusic Z, Despot M (2015) Treatment of patients with anaplastic thyroid cancer during the last 20 years: whether any progress has been made? Eur Arch Otorhinolaryngol 272:1553–1567
Withers HR (1985) Biologic basis for altered fractionation schemes. Cancer 55:2086–2095
Simpson WJ (1980) Anaplastic thyroid carcinoma: a new approach. Can J Surg 23:25–27
Tennvall J, Lundell G, Wahlberg P, Bergenfelz A, Grimelius L, Akerman M et al (2002) Anaplastic thyroid carcinoma: three protocols combining doxorubicin, hyperfractionated radiotherapy and surgery. Br J Cancer 86:1848–1853
Hoie J, Brennhovd IO, Host H, Stenwig AE (1986) Anaplastic thyroid carcinomas. Tidsskr Nor Laegeforen 106:2133–2136
DeLellis RA, Lloyd RV, Heitz PU et al (eds) (2004) World health Organization classification of tumours. Pathology and genetics of tumours of endocrine organs. IARC Press, Lyon
The Norwegian Pathology Association (2007) Nasjonale retningslinjer for diagnostikk og behandling av differensiert cancer thyreoidea. http://www.google.no/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwjU8v681qjRAhUCDywKHasoC24QFggaMAA&url=http%3A%2F%2Flegeforeningen.no%2FFagmed%2FNorsk-endokrinologisk-forening%2FVeiledere-%2FNasjonale-retningslinjer-for-diagnostikk-behandling-og-oppfolging-av-differensiert-cancer-thyreoidea%2F&usg=AFQjCNHXj-ds5nbTD7W127mmYVaEEUYS2g
Wiseman SM, Loree TR, Rigual NR et al (2003) Anaplastic transformation of thyroid cancer: review of clinical, pathologic, and molecular evidence provides new insights into disease biology and future therapy. Head Neck 25:662–670
Wallin G, Bäckdahl M, Tallroth-Ekman E, Lundell G, Auer G, Löwhagen T (1989) Co-existent anaplastic and well differentiated thyroid carcinomas: a nuclear DNA study. Eur J Surg Oncol 15:43–48
Wang Y, Tsang R, Asa S, Dickson B, Arenovich T, Brierley J (2006) Clinical outcome of anaplastic thyroid carcinoma treated with radiotherapy of once- and twice-daily fractionation regimens. Cancer 107:1786–1792
Segerhammar I, Larsson C, Nilsson IL, Backdahl M, Hoog A, Wallin G et al (2012) Anaplastic carcinoma of the thyroid gland: treatment and outcome over 13 years at one institution. J Surg Oncol 106:981–986
Glaser SM, Mandish SF, Gill BS, Balasubramani GK, Clump DA, Beriwal S (2016) Anaplastic thyroid cancer: prognostic factors, patterns of care, and overall survival. Head Neck 38:2083–2090
Swaak-Kragten AT, de Wilt JH, Schmitz PI, Bontenbal M, Levendag PC (2009) Multimodality treatment for anaplastic thyroid carcinoma-treatment outcome in 75 patients. Radiother Oncol 92:100–104
De Crevoisier R, Baudin E, Bachelot A, Leboulleux S, Travagli JP, Caillou B et al (2004) Combined treatment of anaplastic thyroid carcinoma with surgery, chemotherapy, and hyperfractionated accelerated external radiotherapy. Int J Radiat Oncol Biol Phys 60:1137–1143
Dandekar P, Harmer C, Barbachano Y, Rhys-Evans P, Harrington K, Nutting C et al (2009) Hyperfractionated accelerated radiotherapy (HART) for anaplastic thyroid carcinoma: toxicity and survival analysis. Int J Radiat Oncol Biol Phys 74:518–521
Sherman EJ, Lim SH, Ho AL, Ghossein RA, Fury MG, Shaha AR et al (2011) Concurrent doxorubicin and radiotherapy for anaplastic thyroid cancer: a critical re-evaluation including uniform pathologic review. Radiother Oncol 101:425–430
Nachalon Y, Stern-Shavit S, Bachar G et al (2015) Aggressive palliation and survival in anaplastic thyroid carcinoma. JAMA Otolaryngol Head Neck Surg 141:1128–1132
Foote RL, Molina JR, Kasperbauer JL, Lloyd RV, McIver B, Morris JC et al (2011) Enhanced survival in locoregionally confined anaplastic thyroid carcinoma: a single-institution experience using aggressive multimodal therapy. Thyroid 21:25–30
Smallridge RC, Ain KB, Asa SL, Bible KC, Brierley JD, Burman KD et al (2012) American thyroid association guidelines for management of patients with anaplastic thyroid cancer. Thyroid 22:1104–1139
Susanne Singer Susan, Jordan Laura D, Locati et al (2017) The EORTC module for quality of life in patients with thyroid cancer: phase III. Endocr Relat Cancer 24:197–207
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical approval
The study was approved by the Regional Ethical Committee and the hospital’s local authorities, and the patients are fully anonymized in the paper. Permission was given from the Regional Ethical Committee to omit informed consent from the patients, since most of them were dead at the time of data collection.
Conflict of interest
The authors report no conflicts of interest.
Funding
The research was done within the frames of Oslo University Hospital with no external grants.
Rights and permissions
About this article
Cite this article
Jacobsen, AB., Grøholt, K.K., Lorntzsen, B. et al. Anaplastic thyroid cancer and hyperfractionated accelerated radiotherapy (HART) with and without surgery. Eur Arch Otorhinolaryngol 274, 4203–4209 (2017). https://doi.org/10.1007/s00405-017-4764-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00405-017-4764-8