Abstract
We aimed to evaluate the impact of concurrent chemoradiotherapy (CCRT) on the survival of patients with squamous cell carcinoma of the temporal bone. We retrospectively analyzed the data of 13 consecutive patients who were treated by definitive radiation therapy (RT) or CCRT as the initial treatment between 1999 and 2012. There were 5 patients with stage II disease, 5 with stage III, and 3 with stage IV, as classified according to the University of Pittsburgh system. Among these, 2, 4, and 3 patients, respectively, were treated by CCRT; whereas the remaining (3 patients with stage II and 1 with stage III) were treated by RT alone. Median follow-up duration was 39 months (12–106 months) in all cases, and 61.5 months (17–70 months) in censored cases. The 5-year overall survival (OS) rates were 51 % in all patients, and 40, 100, and 0 % in patients with stage II, stage III, and stage IV disease, respectively. In patients with stage II and III disease, the 5-year OS rates were 80 % in the CCRT group and 50 % in the RT-alone group. We found better prognosis in patients with stage II and III disease who were treated by CCRT. Only 2 patients treated by CCRT experienced adverse events more than grade 3, which were neutropenia and dermatitis. There was no late adverse event of bony necrosis. Our study results indicate that CCRT is safe and very effective as a first-line treatment for stage II and III squamous cell carcinoma of the temporal bone.
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References
Arriaga M et al (1990) Staging proposal for external auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings. Ann Otol Rhinol Laryngol 99(9 Pt 1):714–721
Arena S, Keen M (1988) Carcinoma of the middle ear and temporal bone. Am J Otol 9(5):351–356
Hirsch BE (2002) Staging system revision. Arch Otolaryngol Head Neck Surg 128(1):93–94
Clark LJ et al (1991) Squamous carcinoma of the temporal bone: a revised staging. J Laryngol Otol 105(5):346–348
Yin M et al (2006) Analysis of 95 cases of squamous cell carcinoma of the external and middle ear. Auris Nasus Larynx 33(3):251–257
Ogawa K et al (2007) Treatment and prognosis of squamous cell carcinoma of the external auditory canal and middle ear: a multi-institutional retrospective review of 87 patients. Int J Radiat Oncol Biol Phys 68(5):1326–1334
Shiga K et al (2011) Concomitant chemoradiotherapy as a standard treatment for squamous cell carcinoma of the temporal bone. Skull Base 21(3):153–158
Lewis JS (1983) Surgical management of tumors of the middle ear and mastoid. J Laryngol Otol 97(4):299–311
Kinney SE, Wood BG (1987) Malignancies of the external ear canal and temporal bone: surgical techniques and results. Laryngoscope 97(2):158–164
Pensak ML et al (1996) Temporal bone carcinoma: contemporary perspectives in the skull base surgical era. Laryngoscope 106(10):1234–1237
Gidley PW, Roberts DB, Sturgis EM (2010) Squamous cell carcinoma of the temporal bone. Laryngoscope 120(6):1144–1151
Chi FL et al (2011) Survival outcomes in surgical treatment of 72 cases of squamous cell carcinoma of the temporal bone. Otol Neurotol 32(4):665–669
Pignon JP et al (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 355(9208):949–955
Zhang B et al (1999) Squamous cell carcinoma of temporal bone: reported on 33 patients. Head Neck 21(5):461–466
Pemberton LS, Swindell R, Sykes AJ (2006) Primary radical radiotherapy for squamous cell carcinoma of the middle ear and external auditory cana–an historical series. Clin Oncol (R Coll Radiol) 18(5):390–394
Lewis JS (1975) Temporal bone resection. Review of 100 cases. Arch Otolaryngol 101(1):23–25
Golding-Wood DG, Quiney RE, Cheesman AD (1989) Carcinoma of the ear: retrospective analysis of 61 patients. J Laryngol Otol 103(7):653–656
Goodwin WJ, Jesse RH (1980) Malignant neoplasms of the external auditory canal and temporal bone. Arch Otolaryngol 106(11):675–679
Chang CH et al (2009) Treatments and outcomes of malignant tumors of external auditory canal. Am J Otolaryngol 30(1):44–48
Moody SA, Hirsch BE, Myers EN (2000) Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system. Am J Otol 21(4):582–588
Austin JR, Stewart KL, Fawzi N (1994) Squamous cell carcinoma of the external auditory canal. Therapeutic prognosis based on a proposed staging system. Arch Otolaryngol Head Neck Surg 120(11):1228–1232
Manolidis S et al (1998) Temporal bone and lateral skull base malignancy: experience and results with 81 patients. Am J Otol 19(6 Suppl):S1–S15
Prasad S, Janecka IP (1994) Efficacy of surgical treatments for squamous cell carcinoma of the temporal bone: a literature review. Otolaryngol Head Neck Surg 110(3):270–280
Takenaka Y et al (2014) Chemoradiation therapy for squamous cell carcinoma of the external auditory canal: a meta-analysis. Head Neck. doi:10.1002/hed.23698
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Kitani, Y., Kubota, A., Furukawa, M. et al. Primary definitive radiotherapy with or without chemotherapy for squamous cell carcinoma of the temporal bone. Eur Arch Otorhinolaryngol 273, 1293–1298 (2016). https://doi.org/10.1007/s00405-015-3616-7
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DOI: https://doi.org/10.1007/s00405-015-3616-7