Abstract
A definitive relationship between Helicobacter pylori (HP) and upper respiratory tract disorders has not been established. In this case–control study, we investigated the relationship between HP and laryngeal carcinoma by real-time PCR method in Turkey. 74 subjects were enrolled from patients who were admitted to the Otolaryngology Department. Formalin-fixed-paraffin-embedded tissue samples with laryngeal cancer were used and all samples were evaluated by real-time PCR method. Our study population included 72 males and 2 females with a mean age range of 62.7 years. Helicobacter Pylori was detected in only one case. The positive case was also investigated with histopathologic evaluation and HP immunohistochemistry. However, we could not detect HP in this case with both methods. This study revealed that HP might not contribute to the pathogenesis of laryngeal carcinoma. A definitive relationship between HP and upper respiratory tract disorders has not been established.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
https://expertconsult.inkling.com/read/shah-jatin-shahs-head-neck-surgery-oncology-4th/chapter-10/larynx-and-trachea. Accessed 12 Oct 2014
SEER Stat Fact Sheets: Larynx Cancer http://seer.cancer.gov/statfacts/html/laryn.html. Accessed 11 Oct 2014
Gong H, Shi Y, Zhou L et al (2012) Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma. Clin Transl Oncol 14(12):905–910
Shi Y, Gong H, Zhou L et al (2011) Association between Helicobacter pylori infection and laryngeal squamous cell carcinoma in a Chinese male population. ORL J Otorhinolaryngol Relat Spec 73(6):295–300
Chang SS, Jiang WW, Smith I et al (2008) MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer 123(12):2791–2797
Cekin E, Ozyurt M, Erkul E et al (2012) The association between Helicobacter pylori and laryngopharyngeal reflux in laryngeal pathologies. Ear Nose Throat J 91(3):E6–E9
Siupsinskiene N, Jurgutaviciute V, Katutiene I, Janciauskas D, Vaitkus S, Adamonis K (2013) Helicobacter pylori infection in laryngeal diseases. Eur Arch Otorhinolaryngol 270(8):2283–2288
Kariya S, Okano M, Nishizaki K (2014) An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction? World J Gastroenterol 20(6):1470–1484
Burduk PK (2013) Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma. Med Sci Monit 19:584–591
Fellmann J, Weisert JU, Soltermann A et al (2014) Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization. Head Neck 36(11):1562–1566
Akbayir N, Başak T, Seven H, Sungun A, Erdem L (2005) Investigation of Helicobacter pylori colonization in laryngeal neoplasia. Eur Arch Otorhinolaryngol 262(3):170–172
Kraus J, Nártová E, Pavlík E, Katra R, Sterzl I, Astl J (2014) Prevalence of Helicobacter pylori in adenotonsillar hypertrophy in children. Acta Otolaryngol 134(1):88–92
Pajić-Penavić I, Danić D, Maslovara S, Gall-Trošelj K (2012) Absence of Helicobacter pylori in healthy laryngeal mucosa. J Laryngol Otol 126(2):196–199
Roubaud BC, Franceschi F, Salles N, Gasbarrini A (2013) Extragastric diseases and Helicobacter pylori. Helicobacter 18(Suppl 1):44–51
Ozyurt M, Gungor A, Ergunay K, Cekin E, Erkul E, Haznedaroglu T (2009) Real-time PCR detection of Helicobacter pylori and virulence-associated cagA in nasal polyps and laryngeal disorders. Otolaryngol Head Neck Surg 141(1):131–135
Zhuo XL, Wang Y, Zhuo WL, Zhang XY (2008) Possible association of Helicobacter pylori infection with laryngeal cancer risk: an evidence-based meta-analysis. Arch Med Res 39(6):625–628
Titiz A, Ozcakir O, Ceyhan S, Yilmaz YF, Unal A, Akyon Y (2008) The presence of Helicobacter pylori in the larynx pathologies. Auris Nasus Larynx 35(4):534–538
Guilemany JM, Langdon C, Ballesteros F, Blanch JL (2014) Prognostic significance and association of Helicobacter pylori infection in pharyngolaryngeal cancer. Eur Arch Otorhinolaryngol 271(9):2539–2543
Rezaii J, Tavakoli H, Esfandiari K et al (2008) Association between Helicobacter pylori infection and laryngo-hypopharyngeal carcinoma: a case-control study and review of the literature. Head Neck 30(12):1624–1627
Kizilay A, Saydam L, Aydin A, Kalcioglu MT, Ozturan O, Aydin NE (2006) Histopathologic examination for Helicobacter pylori as a possible etiopathogenic factor in laryngeal carcinoma. Chemotherapy 52(2):80–82
Pirzadeh A, Doustmohammadian N, Khoshbaten M, Doustmohammadion S (2011) Is there any association between Helicobacter Pylori infection and laryngeal carcinoma? Asian Pac J Cancer Prev 12(4):897–900
Grandis JR, Perez-Perez GI, Yu VL, Johnson JT, Blaser MJ (1997) Lack of serologic evidence for Helicobacter pylori infection in head and neck cancer. Head Neck 19(3):216–218
Masoud N, Manouchehr K, Najmeh D, Monireh H (2008) Lack of association between Helicobacter pylori and laryngeal carcinoma. Asian Pac J Cancer Prev 9(1):81–82
Rubin JS, Benjamin E, Prior A, Lavy J (2003) The prevalence of Helicobacter pylori infection in malignant and premalignant conditions of the head and neck. J Laryngol Otol 117(2):118–121
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yilmaz, I., Erkul, E., Berber, U. et al. The presence of Helicobacter pylori in laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol 273, 761–765 (2016). https://doi.org/10.1007/s00405-015-3566-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00405-015-3566-0