Abstract
Recently, some studies have noticed a large number of patients with squamous cell carcinoma of the head and neck (SCCHN), who are infected with hepatitis C virus (HCV). The aim of this study is to determine the prevalence of HCV in these patients in our population. Patients with SCCHN in four tertiary centers in different regions of Iran were checked for HCV. The prevalence of HCV in 107 patients diagnosed with head and neck squamous cell carcinoma was 0.9%, which has no significant difference with its prevalence in normal population. It seems that HCV at least in Iran could not be considered as a risk factor for SCCHN.
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References
Chang S, Ha P (2010) Biology of head and neck cancer. In: Flint PW, Haughey BH, Lund VJ, Niparko JK et al (eds) Cummings otolaryngology head and neck surgery. Elsevier Mosby, Philadelphia, pp 1015–1029
Morse DE, Psoter WJ, Cleveland D et al (2007) Smoking and drinking in relation to oral cancer and oral epithelial dysplasia. Cancer Causes Control 18:919–929
Macfarlane TV, Macfarlane GJ, Oliver RJ et al (2010) The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study. Cancer Causes Control 21(12):2213–2221
Hunt J, Hagan J, Nobles J et al (2005) Outcome analysis of patients with squamous cell carcinoma of the head and neck and hepatitis C virus. Laryngoscope 115(10):1882–1886
Nobles J, Wold C, Fazekas-May M, Gilbert J, Friedlander PL (2004) Prevalence and epidemiology of hepatitis C virus in patients with squamous cell carcinoma of the head and neck. Laryngoscope 114(12):2119–2122
Jaber MA, Porter SR, Bain L, Scully C (2003) Lack of association between hepatitis C virus and oral epithelial dysplasia in British patients. Int J Oral Maxillofac Surg 32(2):181–183
Carbone M, Arduino PG, Carrozzo M et al (2009) Course of oral lichen planus: a retrospective study of 808 northern Italian patients. Oral Dis 15(3):235–243
Nagao Y, Sata M (2004) Hepatitis C virus and lichen planus. J Gastroenterol Hepatol 19(10):1101–1113
Nagao Y, Sata M, Tanikawa K, Itoh K, Kameyama T (1995) High prevalence of hepatitis C virus antibody and RNA in patients with oral cancer. J Oral Pathol Med 24(8):354–360
Nagao Y, Sata M (2009) High incidence of multiple primary carcinomas in HCV-infected patients with oral squamous cell carcinoma. Med Sci Monit 15(9):CR453–CR459
Alonso C, Pedroso ML, de Sanjose S et al (1994) Hepatitis C virus among blood donors: follow-up study. Transfusion 34:527–530
Craxi A, Laffi G, Zignego AL (2008) Hepatitis C virus (HCV) infection: a systemic disease. Mol Aspects Med 29(1–2):85–95
Antonelli A, Ferri C, Galeazzi M et al (2008) HCV infection: pathogenesis, clinical manifestations and therapy. Clin Exp Rheumatol 26(1 Suppl 48):S39–S47
Negro F, Alberti A (2011) The global health burden of hepatitis C virus infection. Liver Int 31(Suppl 2):1–3
Zamani S, Ichikawa S, Nassirimanesh B et al (2007) Prevalence and correlates of hepatitis C virus infection among injecting drug users in Tehran. Int J Drug Policy 18(5):359–363
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Eftekharian, A., Khajavi, M., Shokoofi, S. et al. Hepatitis C virus in patients with squamous cell carcinoma of the head and neck in Iran: is there any relation?. Eur Arch Otorhinolaryngol 269, 2571–2573 (2012). https://doi.org/10.1007/s00405-012-1953-3
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DOI: https://doi.org/10.1007/s00405-012-1953-3