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Effects of atosiban on clinical outcome in frozen-thawed embryo transfer: a propensity score matching study

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the effects of atosiban on clinical outcomes in patients undergoing frozen-thawed embryo transfer.

Methods

The clinical data of 1093 infertile patients who underwent frozen-thawed embryo transfer in our center from January 2019 to December 2020 were retrospectively analyzed (control, 418; atosiban, 675). Propensity score matching (PSM) analysis identified 400 matched pairs of patients. The implantation rate, clinical pregnancy rate, live birth rate, biochemical pregnancy rate, abortion rate, multiple pregnancy rate, and ectopic pregnancy rate between the two groups were compared.

Results

Before PSM, patients differed by infertility factors, number of transferred embryos, and endometrial preparation protocol (P < 0.05). After PSM, characteristics were similar in corresponding patients of the atosiban and control groups. After propensity score matching, we found that there was no significant difference in the implantation rate, clinical pregnancy rate, live birth rate, biochemical pregnancy rate, abortion rate, multiple pregnancy rate, and ectopic pregnancy rate in atosiban and control group (P > 0.05).

Conclusion

Atosiban did not improve the clinical outcomes of infertile patients with frozen-thawed embryo transfer.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank all colleagues of the Reproductive Medicine Center, Zhongnan Hospital of Wuhan University.

Funding

This study was supported by the Women and Children's Hospital Discipline Construction Project Fertility Preservation Team Construction Project of Zhongnan Hospital of Wuhan University and the research grant (No. CXPY2022012) from the Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund.

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Authors and Affiliations

  1. Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Hubei Province, No. 169, Wuchang District, East Lake Road, Wuhan City, 430071, China

    Caiyun Ge, Bo Zhang, Yanhong Mao, Zhidan Hong, Chun Zhou, Yan Wang, Mei Wang & Ling Ma

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  1. Caiyun Ge
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  2. Bo Zhang
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  3. Yanhong Mao
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  4. Zhidan Hong
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  5. Chun Zhou
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  6. Yan Wang
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  7. Mei Wang
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  8. Ling Ma
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Ling Ma, Caiyun Ge, and Bo Zhang. The first draft of the manuscript was written by Caiyun Ge and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ling Ma.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethics approval

This project was approved by the Ethics Committee of Zhongnan Hospital of Wuhan University (202217K). This study complies with the Declaration of Helsinki.

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Ge, C., Zhang, B., Mao, Y. et al. Effects of atosiban on clinical outcome in frozen-thawed embryo transfer: a propensity score matching study. Arch Gynecol Obstet 309, 1101–1106 (2024). https://doi.org/10.1007/s00404-023-07289-x

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  • DOI: https://doi.org/10.1007/s00404-023-07289-x

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