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Oxytocin infusion reduces bleeding during abdominal myomectomies: a randomized controlled trial

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the effectiveness of oxytocin infusion to reduce intraoperative bleeding during abdominal myomectomies.

Methods

This randomized, parallel group, blinded study was conducted between October 2017 and May 2018. Patients undergoing abdominal myomectomies were randomized 1:1 either to the oxytocin group or to the control group (saline). In the oxytocin group, 10 IU oxytocin in 500 ml of saline at a rate of 120 ml/h was given during the course of the operation. The primary outcome of this study was to measure intraoperative blood loss between the study groups. Correlation and multiple regression analysis were performed to illustrate factors associated with intraoperative blood loss during the myomectomy.

Results

The mean intraoperative blood loss during the surgery was 489.20 ± 239.72 ml in the oxytocin group and was 641.40 ± 288.21 ml in the control group. The hemoglobin decline was more evident in the control group than in the oxytocin group. Positive correlations were also observed between the intraoperative blood loss and number of fibroids removed during the surgery, largest fibroid removed and weight of fibroids removed. The use of oxytocin infusion during the myomectomy resulted in a reduction of bleeding in the regression model.

Conclusion

Intravenous oxytocin infusion is a safe and practical method to reduce intraoperative blood loss during the abdominal myomectomy.

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, İstanbul Kanuni Sultan Süleyman Training and Research Hospital, Altınşehir, 34303, Halkalı, Istanbul, Turkey

    Berna Aslan Çetin, Nadiye Köroğlu & Ali Soydar

  2. Mother Infant Research Institute at Tufts Medical Center, Boston, MA, USA

    Begüm Aydoğan Mathyk

  3. Obstetrics and Gynecology Department, İstanbul Sadi Konuk Training and Research Hospital, Istanbul, Turkey

    Gökhan Demirayak

  4. Obstetrics and Gynecology Department, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, Turkey

    Tayfur Çift

Authors
  1. Berna Aslan Çetin
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  2. Begüm Aydoğan Mathyk
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  3. Nadiye Köroğlu
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  4. Ali Soydar
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  5. Gökhan Demirayak
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  6. Tayfur Çift
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Contributions

BAÇ: project development, manuscript writing, data analysis. BAM: project development, manuscript editing, data analysis. NK: data collection. AS: data collection. GD: methodology. TÇ: investigation.

Corresponding author

Correspondence to Berna Aslan Çetin.

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Conflict of interest

The author(s) declare that they have no competing interests.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Aslan Çetin, B., Aydoğan Mathyk, B., Köroğlu, N. et al. Oxytocin infusion reduces bleeding during abdominal myomectomies: a randomized controlled trial. Arch Gynecol Obstet 299, 151–157 (2019). https://doi.org/10.1007/s00404-018-4944-9

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  • DOI: https://doi.org/10.1007/s00404-018-4944-9

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