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Serum heme oxygenase-1 levels in patients with primary dysmenorrhea

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Primary dysmenorrhea effects the life-quality of women negatively. The aim of this study was to evaluate heme oxygenase-1 (HO1) activity together with malondialdehyde (MDA) and nitric oxide (NO) levels in patients with primary dysmenorrhea.

Methods

A total of 28 nulliparous women with the diagnosis of primary dysmenorrhea and 26 healthy controls were included in this study. On the first day of menstruation, all patients underwent ultrasound examination to exclude pelvic pathology and the visual analogue scale was applied to patients. Patient’s visual analogue scale (VAS) scores, age, body mass index (BMI), menstrual cycle length (day), length of bleeding (day) were recorded. In the same day, fasting blood samples were taken from each patient for biochemical analysis.

Results

Serum MDA, NO and HO1 levels were found to be higher in women with primary dysmenorrhea compared to healthy controls (p = 0.012, p = 0.009, p < 0.001, respectively). There were no correlation among serum levels of HO1, NO and MDA, age, BMI, cycle length, pain score and menses duration in both groups. In Pearson’s correlation analysis, positive correlation was found between HO1 levels with the NO levels (r = 0.316, p < 0.05) and VAS scores (r = 0.520, p < 0.01). Also, positive correlation was found between MDA levels and VAS scores (r = 0.327, p < 0.05).

Conclusions

Serum HO1, NO and MDA levels increase in patients with primary dysmenorrhea. Antioxidant support might be helpful to reduce pain severity in primary dysmenorrhea.

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Author contributions

ANA: project development, data collection, manuscript writing and editing. EL: project development, data collection and management, manuscript editing. ALO: project development, data analysis, manuscript editing. EPTY: project development, data collection, manuscript writing and editing.

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Authors and Affiliations

  1. Department of Obsterics and Gynecology, Nenehatun Hospital, Dr Refik Saydam Street, Palandöken, 25070, Erzurum, Turkey

    Ayse Nur Aksoy & Emsal Pınar Topdagi Yilmaz

  2. Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey

    Esra Laloglu & Alev Lazoglu Ozkaya

Authors
  1. Ayse Nur Aksoy
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  2. Esra Laloglu
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  3. Alev Lazoglu Ozkaya
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Corresponding author

Correspondence to Ayse Nur Aksoy.

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Funding

This study was not funded.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Aksoy, A.N., Laloglu, E., Ozkaya, A.L. et al. Serum heme oxygenase-1 levels in patients with primary dysmenorrhea. Arch Gynecol Obstet 295, 929–934 (2017). https://doi.org/10.1007/s00404-017-4312-1

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  • DOI: https://doi.org/10.1007/s00404-017-4312-1

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