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Association of −463G/A MPO gene polymorphism and risk of cervical intraepithelial neoplasia

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The MPO system plays an important role in the control of infections and the deletion of malignant cells. Nevertheless, alternations in the MPO system can lead to DNA damage and carcinogenesis. Polymorphisms in the MPO Gene have been associated with an increased expression of MPO and a higher risk for development of cancer. This study evaluates the association between −463G/A MPO gene polymorphism and the risk for CIN.

Methods

The MPO gene polymorphism (−463G/A) was investigated in 616 women with cervical intraepithelial neoplasia and in 206 healthy women. Association between MPO gene polymorphism and risk of cervical intraepithelial neoplasia were analyzed by univariate and multivariable models.

Results

No significant difference in genotype distribution of the MPO gene polymorphism was observed in women with CIN and controls (p = 0.4; OR 1.2, 95 % CI 0.8–1.6). A subgroup analysis only including women with CIN did not show an association between −463G/A MPO gene polymorphism and risk for high-grade CIN (CIN 2/3) (p = 0.09; OR 1.5, 95 % CI 0.9–2.3).

Conclusions

The investigated MPO gene polymorphism is not associated with risk for the development of cervical intraepithelial neoplasia.

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Acknowledgments

The authors would like to thank the women who took part in the study. Special thanks go to Eva Wolf and Andrea Schuster for their critical help at storing and analyzing the study samples.

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Authors and Affiliations

  1. Department of General Gynaecology and Gynaecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Camilla Natter, Stephan Polterauer, Sophie Pils, Dan Cacsire Castillo-Tong, Robert Zeilinger & Christoph Grimm

  2. Center for Medical Statistics, Informatics and Intelligent Systems, Section for Clinical Biometrics, Medical University of Vienna, Vienna, Austria

    Georg Heinze

  3. Department of Gynaecology, Krankenhaus Barmherzige Schwestern, Linz, Austria

    Lukas Hefler

Authors
  1. Camilla Natter
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  2. Stephan Polterauer
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  3. Sophie Pils
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  4. Dan Cacsire Castillo-Tong
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  5. Robert Zeilinger
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  6. Georg Heinze
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  7. Lukas Hefler
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  8. Christoph Grimm
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Corresponding author

Correspondence to Camilla Natter.

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Natter, C., Polterauer, S., Pils, S. et al. Association of −463G/A MPO gene polymorphism and risk of cervical intraepithelial neoplasia. Arch Gynecol Obstet 293, 865–869 (2016). https://doi.org/10.1007/s00404-015-3869-9

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  • DOI: https://doi.org/10.1007/s00404-015-3869-9

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