Skip to main content
SpringerLink
Log in

Effects of fetal cardiac anomalies on ductus venosus and aortic isthmus doppler profiles

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To demonstrate the blood flow profiles of fetuses with cardiac anomalies at the level of Ductus venosus (DV) and Aortic isthmus (AI) to evaluate the effects of fetal cardiac anomalies on these profiles, and how these profile changes contribute to cardiac anomaly screening studies as a marker.

Methods

DV and AI doppler studies were applied to 64 singleton pregnant women with fetal cardiac anomalies and 74 pregnant women with healthy fetuses. DV-PVIV (peak velocity index for veins) for DV and IFI (isthmic flow index) for AI were used.

Results

DV doppler studies in fetuses with cardiac anomalies and healthy fetuses did not show statistically significant difference. But the results of the AI doppler studies had statistically significant difference in the fetal cardiac anomaly group with the exception of cases with dilatation and regurgitation. When right-sided heart anomaly and the remaining cases were compared with the control groups, AI doppler results also showed lower IFI values.

Conclusions

DV doppler studies in the second or third trimester may not be suitable as a screening test for congenital heart disease, but AI doppler studies might be considered as a supporting parameter. But further studies are needed for routine clinical use.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aydoğan Ü (2000) Fetal ve neonatal dolaşım. In: Dadaloğlu T (ed) Neonataloji. Nobel tıp kitapevleri, Ankara, pp 387–390

  2. Bernstein D (2000) Epidemiology and genetic basis of congenital heart disease. In: Berhman RE, Kliegman RM, Jenson HB (eds) Nelson texbook of pediatrics, 16.baskı. W.B. saunders Company, Philadephia, pp 1499–1502

  3. Brennan P, Young ID (2001) Congenital heart malformations: etiology and associations. 6:17–25

    CAS  Google Scholar 

  4. Dawes GS (1962) The umbilical circulation. Am J Obstet Gynecol 84:1634

    PubMed  CAS  Google Scholar 

  5. Guyton AC, Hall JE (1996) Fetal ve neonatal fizyoloji. In: Guyton AC, Hall JE. Çeviri Ed. Çavuşoğlu H (eds) Tıbbi Fizyoloji, 19. baskı (Türkçe), Nobel Kitap evi, İstanbul, pp 1047–1056

  6. Gürakan B (2004) Konjenital kalp hastalıklarının değerlendirilmesi. In: Yurdakök M, Erdem G (eds) Neonataloji. Ankara 63, pp 503–512

  7. Edwards WD (2001) Classification and terminology of cardiovascular anomalies. In: Allen HD, Gutgesell HP, Clark EB, Driscoll DJ (eds) Moss & Adams heart disease in infants, children, and adolescent including the fetus and young adult, 6.baskı. Lippincott Williams and Wilkins, Philadelphia, pp 118–137

  8. Kisslo J, Adams D, Leech G (2000) The use of echocardiography in congenital heart disease. Essentials of echocardiography http://www.echoincontext.com

  9. Kovalchin JP, Silverman NH (2004) The impact of fetal echocardiography. Pediatr Cardiol 25(3):299–306

  10. Brown R, Di Luzio L, Gomes C, Nicolaides KH (1998) The umbilical artery pulsatility index in the first trimester: is there an association with increased nuchal translucency or chromosomal abnormality? Ultrasound Obstet Gynecol 12:244–247

    Article  PubMed  CAS  Google Scholar 

  11. Haak MC, Twisk JW, Bartelings MM, Gittenberger-de Groot AC, van Vugt JM (2003) Ductus venosus flow velocities in relation to the cardiac defects in first-trimester fetuses with enlarged nuchal translucency. Am J Obstet Gynecol 188:727–733

  12. Huisman TWA, Bilardo CM (1997) Transient increase in nuchal translucency thickness and reversed end-diastolic ductus venosus flow in a fetus with trisomy 18. Ultrasound Obstet Gynecol 10:397–399

    Article  PubMed  CAS  Google Scholar 

  13. Borrell A (2004) The ductus venosus in early pregnancy and congenital anomalies. Prenat Diagn 24:688–692

    Article  PubMed  Google Scholar 

  14. DeVore GR, Horenstein J (1993) Ductus venosus index: a method for evaluating right ventricular preload in the secondtrimester fetus. Ultrasound Obstet Gynecol 3:338–342

    Article  PubMed  CAS  Google Scholar 

  15. Kiserud T (2001) The ductus venosus. Semin Perinatol 25:11–20

    Article  PubMed  CAS  Google Scholar 

  16. Kiserud T, Rasmussen S, Skulstad S (2000) Blood flow and the degree of shunting through the ductus venosus in the human fetus. Am J Obstet Gynecol 182:147–153

    Article  PubMed  CAS  Google Scholar 

  17. Fouron JC, Gosselin J, Amiel-Tison C et al (2001) Correlation between prenatal velocity waveforms in the aortic isthmus and neurodevelopmental outcomes between the ages of 2 and 4 years. Am J Obstet Gynecol 184:630–636

    Article  PubMed  CAS  Google Scholar 

  18. Makikallio K, Jouppila P, Rasanen J (2003) Retrograde aortic isthmus net blood flow and human fetal cardiac function in placental insufficiency. Ultrasound Obstet Gynecol 22:351–357

  19. Antolín E, Comas C, Torrents M, Muñoz A, Figueras F, Echevarría M, Cararach M, Carrera JM (2001) The role of ductus venosus blood flow assessment in screening for chromosomal abnormalities at 10–16 weeks of gestation. Ultrasound Obstet Gynecol 17:295–300

    Article  PubMed  Google Scholar 

  20. Bilardo CM, Müller MA, Zikulnig L, Schipper M, Hecher K (2001) Ductus venosus studies in fetuses at high risk for chromosomal or heart abnormalities: relationship with nuchal translucency measurement and fetal outcome. Ultrasound Obstet Gynecol 17:288–294

    Article  PubMed  CAS  Google Scholar 

  21. Borrell A, Antolin E, Costa D, Farre T, Martinez JM, Fortuny A (1998) Abnormal ductus venosus blood flow in trisomy 21 fetuses during early pregnancy. Am J Obstet Gynecol 179:1612–1617

    Article  PubMed  CAS  Google Scholar 

  22. Matias A, Gomes C, Flack N, Montenegro N, Nicolaides KH (1998) Screening for chromosomal abnormalities at 10–14 weeks: the role of ductus venosus blood flow. Ultrasound Obstet Gynecol 12:380–384

    Article  PubMed  CAS  Google Scholar 

  23. Gembruch U, Meise C, Germer U, Berg C, Geipel A (2003) Venous Doppler ultrasound in 146 fetuses with congenital heart disease. Ultrasound Obstet Gynecol 22:345–350

    Article  PubMed  CAS  Google Scholar 

  24. Berg C, Kremer C, Geipel A (2006) Ductus venosus blood flow alterations in fetuses with obstructive lesions of the heart. Ultrasound Obstet Gynecol 28:137–142

    Article  PubMed  CAS  Google Scholar 

  25. Bonnin P, Fouron JC, Teyssier G, Sonesson SE, Skoll A (1993) Quantitative assessment of circulatory changes in the fetal aortic isthmus during progressive increase of resistance to umbilical blood flow. Circulation 88:216–222

    Article  PubMed  CAS  Google Scholar 

  26. Ruskamp J, Fouron JC, Gosselin J, Raboisson MJ, Infante-Rivard C, Proulx F (2003) Reference values for an index of fetal aortic isthmus blood flow during the second half of pregnancy. Ultrasound Obstet Gynecol 21:441–444

  27. Mari G, Deter RL (1992) Middle cerebral artery flow velocity waveforms in normal and small-for-gestational-age fetuses. Am J Obstet Gynecol 166:1262–1270

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Suleymaniye Research and Education Hospital, Istanbul, Turkey

    Gülşah İlhan & Ali Galip Zebitay

  2. İstanbul University İstanbul Medical Faculty, Istanbul, Turkey

    Ahmet Cem İyibozkurt, Halil İbrahim Kalelioğlu & Lemi İbrahimoğlu

  3. Zeynep Kamil Research and Education Hospital, Istanbul, Turkey

    Meryem Kürek Eken

  4. Balıkesir State Hospital, Balıkesir, Turkey

    Ayşe Filiz Gökmen Karasu

Authors
  1. Gülşah İlhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ahmet Cem İyibozkurt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Halil İbrahim Kalelioğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lemi İbrahimoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ali Galip Zebitay
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Meryem Kürek Eken
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ayşe Filiz Gökmen Karasu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gülşah İlhan.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest. The authors have full control of all primary data and they agree to allow the journal to review their data if requested.

Ethics committee approval

Ethics committee approval was received for this report from the local ethics committee.

Informed consent

Written informed consent was obtained from patient who participated in this study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

İlhan, G., İyibozkurt, A.C., Kalelioğlu, H.İ. et al. Effects of fetal cardiac anomalies on ductus venosus and aortic isthmus doppler profiles. Arch Gynecol Obstet 293, 345–350 (2016). https://doi.org/10.1007/s00404-015-3796-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-015-3796-9

Keywords

Search

Navigation