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Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women

  • General Gynecology
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The objective of this study was to determine the changes in total plasma thiols (homocysteine, cysteine and cysteinylglycine), lipid peroxidation and nitric oxide concentrations during normal pregnancy.

Methods

These variables were measured in 28 uncomplicated pregnant women at first, second and third trimesters and in 19 nonpregnant women.

Results

The mean concentrations of homocysteine, cysteine and cysteinylglycine were significantly lower in all trimesters of pregnancy compared with nonpregnant controls. There was significant elevation in serum lipid peroxidation levels of pregnant women within first and third trimesters compared with nonpregnant women. In spite of increase in mean nitric oxide levels in pregnant women, this increase did not reach statistically significant levels.

Conclusion

This study provides information about the changes in plasma levels of many variables having important role in pregnancy complication during all trimesters in uncomplicated pregnancy compared with nonpregnant women.

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Acknowledgments

This study was supported by Gazi University Research Fund (Project No: 02/2001-22).

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Pharmacy, Gazi University, 06330, Etiler-Ankara, Turkey

    Yesim Ozkan, Sevgi Yardim-Akaydin & Bolkan Şimşek

  2. Department of Obstetrics and Gynecology, Faculty of Medicine, Gazi University, Beşevler-Ankara, Turkey

    Ahmet Erdem

Authors
  1. Yesim Ozkan
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  2. Sevgi Yardim-Akaydin
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  3. Ahmet Erdem
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  4. Bolkan Şimşek
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Correspondence to Yesim Ozkan.

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Ozkan, Y., Yardim-Akaydin, S., Erdem, A. et al. Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women. Arch Gynecol Obstet 285, 1319–1324 (2012). https://doi.org/10.1007/s00404-011-2150-0

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  • DOI: https://doi.org/10.1007/s00404-011-2150-0

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