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Association of interleukin-6 in women with persistence of DNA-HPV: a nested case–control study

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To identify the role of Interleukin-6, IL-10 and their epidemiological association in women with persistence of DNA-HPV.

Design and methods

A nested case–control study within a longitudinal cohort study. Cervical specimens and blood samples were collected at enrolment from asymptomatic women who looked for a service of public health in a district of Porto Alegre, Brazil. A logistic regression analysis was performed with 95% confidence intervals. The outcome was the persistence of DNA-HPV infection.

Results

The analysis showed that the age of the first intercourse below 20 years old (OR = 19.65, IC 95% 2.43–68.85), four or more sexual partners during lifetime (OR = 5.67, IC 95% 1.28–24.99), women with a previous altered Pap smear (OR = 10.17, IC 95% 1.80–57.33), marital status (OR = 12.94, IC 95% 2.43–68.85) and IL6 ≤ 3.106 pg/ml were associated with persistence of HPV infection. IL-10 were not associated with the HPV persistence.

Conclusion

The present study suggests that IL-6 levels may be a marker of HPV DNA persistence, although further investigation is necessary.

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Acknowledgments

This research was funded by the National Council of Scientific and Technological Development (CNPq), Brazil; MC Bozzetti is a recipient of a research award from the CNPq.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Laboratory of Epidemiology and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, University of the Extreme-South Catarinense, Criciuma, Brazil

    Maria Inês Rosa, Matheus Villas Moraes & Fábio Rosa Silva

  2. Experimental Physiopathology Laboratory, Postgraduate Program in Health Sciences, University of the Extreme-South Catarinense, Criciuma, Brazil

    Francieli Vuolo & Felipe Dal-Pizzol

  3. Experimental Immunopathology Laboratory, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Santa Catarina, Brazil

    Fabricia Petronilho

  4. Postgraduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

    Fabricia Petronilho

  5. Postgraduate Program in Medicine, Medical Sciences at Federal University of Rio Grande do Sul, Porto Alegre, Brazil

    Mary Clarisse Bozzetti, Lidia Rosi Medeiros, Cristine Nascente Igansi & Daniela Dorneles Rosa

  6. Fêmina Hospital, Conceição Hospitalar Group, Porto Alegre, Brazil

    Daniela Dorneles Rosa

Authors
  1. Maria Inês Rosa
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  2. Matheus Villas Moraes
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Correspondence to Maria Inês Rosa.

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Rosa, M.I., Moraes, M.V., Vuolo, F. et al. Association of interleukin-6 in women with persistence of DNA-HPV: a nested case–control study. Arch Gynecol Obstet 285, 143–148 (2012). https://doi.org/10.1007/s00404-011-1925-7

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  • DOI: https://doi.org/10.1007/s00404-011-1925-7

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