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Interleukin-6 levels in hyperemesis gravidarum

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Abstract

Introduction.

Hyperemesis gravidarum (HG) is associated with higher levels of serum β-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of β-hCG from trophoblastic cell line.

Methods.

We measured serum levels of IL-6, thyroid hormones and β-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups.

Results.

There was a significant difference in β-hCG (p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with β-hCG (r=0.38 and p=0.13).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, Celal Bayar University, 45020, Manisa, Turkey

    Naci K. Kuscu, Yasemin Yildirim & Faik Koyuncu

  2. Department of Biochemistry, School of Medicine, Celal Bayar University, 45020, Manisa, Turkey

    Ahmet Var & Bekir S. Uyanik

Authors
  1. Naci K. Kuscu
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  2. Yasemin Yildirim
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  3. Faik Koyuncu
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  4. Ahmet Var
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  5. Bekir S. Uyanik
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Correspondence to Naci K. Kuscu.

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Kuscu, N.K., Yildirim, Y., Koyuncu, F. et al. Interleukin-6 levels in hyperemesis gravidarum. Arch Gynecol Obstet 269, 13–15 (2003). https://doi.org/10.1007/s00404-002-0412-6

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  • DOI: https://doi.org/10.1007/s00404-002-0412-6

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