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Association of glutathione S-transferase pi (GSTP1) Ile105Val polymorphism with the risk of skin cancer: a meta-analysis

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Abstract

Numerous epidemiological studies have evaluated the association of Glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with the risk of skin cancer. However, the results remain inconclusive. To derive a more precise estimation of the association between the GSTP1 Ile105Val polymorphism and skin cancer risk, a meta-analysis was performed. A comprehensive search was conducted to identify the eligible studies. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the association of GSTP1 Ile105Val polymorphism with skin cancer risk. Thirteen case–control studies in nine articles, which included a total of 1504 cases and 2243 controls. Overall, we found that GSTP1 Ile105Val polymorphism was not associated with skin cancer risk. Furthermore, subgroup analysis by histological types showed that GSTP1 Ile105Val polymorphism was associated with risks of malignant melanoma under the dominant model (Val/Val + Val/Ile vs. Ile/Ile: OR 1.230, 95 % CI 1.017–1.488, P = 0.033). However, lack of association between GSTP1 Ile105Val polymorphism and BCC and SCC risk in all genetic models. Our meta-analysis suggested that the GSTP1 Ile105Val polymorphism might be associated with increased risk of malignant melanoma in Caucasian population.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (81441090, 81371730), the Specialized Research Fund for the Doctoral Program of Higher Education (20133420110001) and Grant for Scientific Research of BSKY (XJ201418) from Anhui Medical University.

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The authors declare no conflict of interest.

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    Authors and Affiliations

    1. Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China

      Cheng-Fan Zhou, Tong Shen & Qi-Xing Zhu

    2. Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China

      Cheng-Fan Zhou, Tong Shen & Qi-Xing Zhu

    3. Department of Oncology, the First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China

      Tai Ma

    4. Department of Emergency Medicine, the First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China

      Deng-Chuan Zhou

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    1. Cheng-Fan Zhou
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    Correspondence to Qi-Xing Zhu.

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    C. Zhou and T. Ma have contributed equally to this work.

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    Zhou, CF., Ma, T., Zhou, DC. et al. Association of glutathione S-transferase pi (GSTP1) Ile105Val polymorphism with the risk of skin cancer: a meta-analysis. Arch Dermatol Res 307, 505–513 (2015). https://doi.org/10.1007/s00403-015-1576-9

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    • DOI: https://doi.org/10.1007/s00403-015-1576-9

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