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Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review

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Abstract

Burn wound healing is a complicated process including inflammation, re-epithelialization, granulation, neovascularization and wound contraction. Several biochemicals are involved in burn healing process including antioxidants, cytokines and liver and kidney damage biomarkers. Although several preparations are available for the management of burn wound, there is still a necessity of researching for efficacious medicine. The aim of the present study was to evaluate herbal preparations and their phytochemical constituents for burn wound management. For this purpose, electronic databases including Pubmed, Scirus, Scopus and Cochrane library were searched from 1966 to July 2013 for in vitro, in vivo or clinical studies which examined the effect of any herbal preparation on different types of burn wound. Only 3 human studies were found to include in this review. In contrast, there were 62 in vivo and in vitro studies that show the need for more clinical trials to prove the plant’s potential to cure burn wound. Among single herbal preparations, Allium sativum, Aloe vera, Centella asiatica and Hippophae rhamnoides showed the best burn wound healing activity. Flavonoids, alkaloids, saponins and phenolic compounds were active constituents present in different herbs facilitating wound closure. Glycosides including madecassoside and asiaticoside and proteolytic enzymes were among the main active components. Phytochemicals represented positive activity at different stages of burn wound healing process by various mechanisms including antimicrobial, anti-inflammatory, antioxidant, collagen synthesis stimulation, cell proliferative and angiogenic effect. Overall, several herbal medicaments have shown marked activity in the management of wounds—especially burn wounds—and therefore can be considered as an alternative source of treatment. Furthermore, various natural compounds with verified burn-induced wound healing potential can be assumed as future natural drugs.

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References

  1. Aghili MH (2009) Makhzan-al-Advia. Rahimi R, Shams-Ardekani MR, Farjadmand F (eds) Tehran University of Medical Sciences, Tehran http://aqlibrary.org/UserFiles/File/makhzan.pdf

  2. Amini M, Kherad M, Mehrabani D et al (2010) Effect of Plantago major on burn wound healing in rat. J Appl Anim Res 37(1):53–56

    Article  Google Scholar 

  3. Ananth KV, Asad M, Prem kumar N et al (2010) Evaluation of wound healing potential of Bauhinia purpurea leaf extracts in rats. Indian J Pharm Sci 72(1):122–127

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Ashkani-Esfahani S, Imanieh MH, Khoshneviszadeh M et al (2012) The healing effect of Arnebia euchroma in second degree burn wounds in rat as an animal model. Iran Red Crescent Med J 14(2):70–74

    CAS  PubMed Central  PubMed  Google Scholar 

  5. Avicenna (1983) The Cannon of Medicine. Sorush Publication, Tehran

    Google Scholar 

  6. Babu SG, Bairy KL (2003) Effect of Tridax procumbens on burn wound healing. Indian Drugs 40(8):488–491

    Google Scholar 

  7. Barua CC, Talukdar A, Begum S et al (2012) Effect of Alternanthera brasiliana (L.) Kuntze on healing of dermal burn wound. Indian J Exp Biol 50(1):56–60

    Google Scholar 

  8. Barua CC, Talukdar A, Begum S et al (2012) In vivo wound-healing efficacy and antioxidant activity of Achyranthes aspera in experimental burns. Pharm Biol 50(7):892–899

    Article  PubMed  Google Scholar 

  9. Biswas TK, Maity LN, Mukherjee B (2004) Wound healing potential of Pterocarpus santalinus Linn: a pharmacological evaluation. Int J Low Extrem Wounds 3(3):143–150

    Article  PubMed  Google Scholar 

  10. Chandran PK, Kuttan R (2008) Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defense mechanism and granuloma formation during thermal burns. J Clin Biochem Nutr 43(2):58–64

    Article  PubMed Central  PubMed  Google Scholar 

  11. Csupor D, Blazso G, Balogh A et al (2010) The traditional Hungarian medicinal plant Centaurea sadleriana Janka accelerates wound healing in rats. J Ethnopharmacol 127(1):193–195

    Article  PubMed  Google Scholar 

  12. Deveci M, Eski M, Sengezer M et al (2000) Effects of cerium nitrate bathing and prompt burn wound excision on IL-6 and TNF-α levels in burned rats. Burns 26(1):41–45

    Article  CAS  PubMed  Google Scholar 

  13. Djerrou Z, Maameri Z, Hamdi-pacha Y et al (2010) Effect of virgin fatty oil of Pistacia lentiscus on experimental burn wound’s healing in rabbits. Afr J Tradit Complement Altern Med 7(3):258–263

    PubMed Central  PubMed  Google Scholar 

  14. Duansak D, Somboonwong J, Patumraj S (2003) Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats. Clin Hemorheol Microcirc 29(3–4):239–246

    CAS  PubMed  Google Scholar 

  15. Dumville JC, Munson C (2012) Negative pressure wound therapy for partial-thickness burns. Cochrane Database Sys Rev 12:CD006215

  16. Dursun N, Liman N, Ozyazgan I et al (2003) Role of thymus oil in burn wound healing. J Burn Care Rehabil 24(6):395–399

    Article  PubMed  Google Scholar 

  17. Dwivedi VK, Chaudhary M, Ahmad A et al (2010) Comparative efficacy of ampucare and silver sulfadiazine against burn wound rat. J Appl Sci Res 6(6):674–682

    CAS  Google Scholar 

  18. Farzaei M, Rahimi R, Abbasabadi Z et al (2013) An evidence-based review on medicinal plants used for treatment of peptic ulcer in traditional Iranian medicine. Int J Pharmacol 9(2):108–124

    Article  Google Scholar 

  19. Farzaei M, Shams-Ardekani M, Abbasabadi Z et al (2013) Scientific evaluation of edible fruits and spices used for the treatment of peptic ulcer in traditional Iranian medicine. ISRN Gastroentrol, ID 136932

    Google Scholar 

  20. Ganjali A, Sotoudeh A, Jahanshahi A et al (2013) Otostegia persica extraction on healing process of burn wounds. Acta Cir Bras 28(6):407–411

    Article  PubMed  Google Scholar 

  21. Ghasemi Pirbalouti A, Azizi S, Koohpayeh A (2012) Healing potential of Iranian traditional medicinal plants on burn wounds in alloxan-induced diabetic rats. Rev Bras Farmacogn 22(2):397–403

    Article  Google Scholar 

  22. Gomes FSL, Spinola CDV, Ribeiro HA et al (2010) Wound-healing activity of a proteolytic fraction from Carica candamarcensis on experimentally induced burn. Burns 36(2):277–283

    Article  PubMed  Google Scholar 

  23. Gurfinkel R, Palivatkel-Naim M, Gleisinger R et al (2012) Comparison of purified olive oil and silver sulfadiazine in the treatment of partial thickness porcine burns. Am J Emerg Med 30(1):79–83

    Article  PubMed  Google Scholar 

  24. Gurung S, kalko-Basnet N (2009) Wound healing properties of Carica papaya latex: in vivo evaluation in mice burn model. J Ethnopharmacol 121(2):338–341

    Article  CAS  PubMed  Google Scholar 

  25. Hafezi F, Elmi rad H, Naghibzadeh B et al (2010) Actinidia deliciosa (kiwifruit), a new drug for enzymatic debridement of acute burn wounds. Burns 36(3):352–355

    Article  PubMed  Google Scholar 

  26. Hajhashemi V, Ghannadi A, Heidari AH (2012) Anti-inflammatory and wound healing activities of Aloe littoralis in rats. Res Pharm Sci 7(2):73–78

    CAS  PubMed Central  PubMed  Google Scholar 

  27. Hassanzadeh G, Hajmanouchehri F, Beheshti roi A et al (2013) Comparing effects of Silver sulfadiazine, Sucralfate and Brassica oleracea extract on burn wound healing. Life Sci J 10(6s):852–861

    Google Scholar 

  28. Hosseinimehr SJ, Khorasani Gh, Azadbakht M et al (2010) Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats. Acta Dermatovenerol Croat 18(1):2–7

    PubMed  Google Scholar 

  29. Chandramohan BJ, Reddy DN (2006) Burn wound healing activity of Euphorbia hirta. Anc Sci Life 25(3–4):16–18

    PubMed Central  PubMed  Google Scholar 

  30. Jarrahi M (2008) An experimental study of the effects of Matricaria chamomilla extract on cutaneous burn wound healing in albino rats. Nat Prod Res 22(5):422–427

    Article  CAS  PubMed  Google Scholar 

  31. Karimi M, Parsaei P, Asadi SY et al (2013) Effects of Camellia sinensis ethanolic extract on histometric and histopathological healing process of burn wound in rat. Middle-East J Sci Res 13(1):14–19

    Google Scholar 

  32. Kawahira K, Sumiyoshi M, Sakanaka M et al (2008) Effects of ginsenoside Rb 1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas during the process of acute burn wound repair. J Ethnopharmacol 117(2):278–284

    Article  CAS  PubMed  Google Scholar 

  33. Khorasani G, Hosseinimeh SJ, Zamani P et al (2008) The effect of saffron (Crocus sativus) extract for healing of second-degree burn wounds in rats. Keio J Med 57(4):190–195

    Article  PubMed  Google Scholar 

  34. Kimura Y, Sumiyoshi M, Kawahira K et al (2006) Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice. Br J Pharmacol 148(6):860–870

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  35. Kimura Y, Sumiyoshi M, Sakanaka M (2007) Effects of Astilbe thunbergii rhizomes on wound healing Part 1. Isolation of promotional effectors from Astilbe thunbergii rhizomes on burn wound healing. J Ethnopharmacol 109(1):72–77

    Article  PubMed  Google Scholar 

  36. Kimura Y, Sumiyoshi M, Samukawa K et al (2008) Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. Eur J Pharmacol 584(2):415–423

    Article  CAS  PubMed  Google Scholar 

  37. Kiran K, Asad M (2008) Wound healing activity of Sesamum indicum L. seed and oil in rats. Indian J Exp Biol 46(11):777–782

    PubMed  Google Scholar 

  38. Kumar B, Vijayakumar M, Govindarajan R et al (2007) Ethnopharmacological approaches to wound healing-exploring medicinal plants of India. J Ethnopharmacol 114(2):103–113

    Article  CAS  PubMed  Google Scholar 

  39. Kumari S, Harjai K, Chhibber S (2010) Topical treatment of Klebsiella pneumoniae B5055 induced burn wound infection in mice using natural products. J Infect Dev Ctries 4(6):367–377

    PubMed  Google Scholar 

  40. Liu M, Dai Y, Li Y et al (2008) Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice. Planta Med 74(8):809–815

    Article  CAS  PubMed  Google Scholar 

  41. Lodhi S, Pawar RS, Jain AP et al (2010) Effect of Tephrosia purpurea (L.) pers. On partial thickness and full thickness burn wounds in rats. J Complement Integr Med. doi:10.2202/1553-3840.1344

  42. Lv RL, Wu BY, Chen XD et al (2006) The effects of aloe extract on nitric oxide and endothelin levels in deep-partial thickness burn wound tissue in rat. Zhonghua Shao Shang Za Zhi 22(5):362–365

    PubMed  Google Scholar 

  43. Majumdar M, Nayeem N, Kamath JK et al (2007) Evaluation of Tectona grandis leaves for wound healing activity. Pak J Pharm Sci 20(2):120–124

    PubMed  Google Scholar 

  44. Matheson JD, Clayton J, Muller MJ (2001) The reduction of itch during burn wound healing. J Burn Care Rehabil 22(1):76–81

    Article  CAS  PubMed  Google Scholar 

  45. Moghaddam PZ, Zolfaghari MR, Ghasemi E et al (2011) Negative performance of root extract of Onosma dichroanthum Boiss. on the burn wound healing in an animal model. Arc Microbiol 2(5):1–5

  46. Mohajeri G, Masoudpour H, Heidarpour M et al (2010) The effect of dressing with fresh kiwifruit on burn wound healing. Surgery 148(5):963–968

    Article  PubMed  Google Scholar 

  47. Nayak B, Raju S, Ramsubhag A (2008) Investigation of wound healing activity of Lantana camara L. in Sprague dawley rats using a burn wound model. Int J Appl Res Nat Prod 1(1):15–19

    Google Scholar 

  48. Ogurtan Z, Hatipoglu F, Ceylan C (2002) The effect of Alkanna tinctoria Tausch on burn wound healing in rabbits. Dtsch Tierarztl Wochenschr 109(11):481–485

    CAS  PubMed  Google Scholar 

  49. Priya KS, Arumugam G, Rathinam B et al (2004) Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model. Wound Repair Regen 12(6):618–625

    Article  PubMed  Google Scholar 

  50. Priya KS, Gnanamani A, Radhakrishnan N et al (2002) Healing potential of Datura alba on burn wounds in albino rats. J Ethnopharmacol 83(3):193–199

    Article  PubMed  Google Scholar 

  51. Rahimi R, Abdollahi M (2012) Herbal medicines for the management of irritable bowel syndrome: a comprehensive review. World J Gastroenterol 18(7):589–600

    Article  PubMed Central  PubMed  Google Scholar 

  52. Rodriguez-Bigas M, Cruz NI, Suarez A (1988) Comparative evaluation of Aloe vera in the management of burn wounds in guinea pigs. Plast Reconstr Surg 81(3):386–389

    Article  CAS  PubMed  Google Scholar 

  53. Sakarcan A, Sehirli O, Velioglu-ovunc A et al (2005) Ginkgo biloba extract improves oxidative organ damage in a rat model of thermal trauma. J Burn Care Rehabil 26(6):515–524

    Article  PubMed  Google Scholar 

  54. Sanwal R, Chaudhary AK (2011) Wound healing and antimicrobial potential of Carissa spinarum Linn. in albino mice. J Ethnopharmacol 135(3):792–796

    Article  PubMed  Google Scholar 

  55. Sehgal R, Manu C, Vivek D et al (2010) Efficacy evaluation of ampucare in comparison with silver sulfadiazine in burn wound healing in rats. Int J Drug Dev Res 2(1):85–88

    Google Scholar 

  56. Sener G, Sariroglu H, Sehirli O et al (2003) Protective effect of aqueous garlic extract against oxidative organ damage in a rat model of thermal injury. Life Sci 73(1):81–91

    Article  CAS  PubMed  Google Scholar 

  57. Shahzad MN, Ahmed N (2013) Effectiveness of Aloe vera gel compared with 1 % silver sulphadiazine cream as burn wound dressing in second degree burns. J Pak Med Assoc 63(2):225–230

    PubMed  Google Scholar 

  58. Shanbhag T, Amuthan A, Shenoy S (2010) Effect of Phyllanthus niruri. Linn on burn wound in rats. Asian Pac J Trop Med 3(2):105–108

    Article  Google Scholar 

  59. Shanbhag T, Kodidela S, Shenoy S et al (2011) Effect of Michelia champaca linn flowers on burn wound healing in wistar rats. Int J Pharm Sci Rev Res 7(2):112–115

    Google Scholar 

  60. Jalali SSF, Saifzadeh S, Tajik H et al (2008) The efficacy of aqueous extract of Iranian garlic on the healing of burn wound: a clinical and microbiological study. Asian J Anim Vet Adv 3(3):162–168

    Article  Google Scholar 

  61. Jalali SSF, Tajik H, Hadian M (2012) Efficacy of topical application of alcoholic extract of yarrow in the healing process of experimental burn wounds in rabbit. Comp Clin Pathol 21(2):177–181

    Article  Google Scholar 

  62. Jalali SSF, Tajik H, Javadi H et al (2009) The efficacy of alcoholic extract of garlic on the healing process of experimental burn wound in the rabbit. J Anim Vet Adv 8(4):655–659

    Google Scholar 

  63. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341(10):738–746

    Article  CAS  PubMed  Google Scholar 

  64. Somboonwong J, Kankaisre M, Tantisira B et al (2012) Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study. BMC Complement Altern Med 12:103

    Article  PubMed Central  PubMed  Google Scholar 

  65. Somboonwong J, Thanamittramanee S, Jariyanpongskul A et al (2000) Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thai 83(4):417–425

    CAS  PubMed  Google Scholar 

  66. Srivastava P, Durgaprasad S (2008) Burn wound healing property of Cocos nucifera: an appraisal. Indian J Pharmacol 40(4):144–146

    Article  PubMed Central  PubMed  Google Scholar 

  67. Tajik H, Jalali SSF, Javadi S et al (2009) Clinical and microbiological evaluations of efficacy of combination of natural honey and yarrow on repair process of experimental burn wound. J Anim Vet Adv 8(5):907–911

    Article  Google Scholar 

  68. Thakur R, Jain N, Pathak R et al (2011) Practices in wound healing studies of plants. Evid Based Complement Alternat Med. doi:10.1155/2011/438056

  69. Toklu HZ, Tunaly-Akbay T, Erkanli G et al (2007) Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns 33(7):908–916

    Article  PubMed  Google Scholar 

  70. Upadhyay NK, Kumar R, Mandotra SK et al (2009) Safety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in rats. Food Chem Toxicol 47(6):1146–1153

    Article  CAS  PubMed  Google Scholar 

  71. Upadhyay NK, Kumar R, Sidiqui MS et al (2011) Mechanism of wound-healing activity of Hippophae rhamnoides L. leaf extract in experimental burns. Evid Based Complement Alternat Med. doi:10.1093/ecam/nep189

  72. Visuthikosol V, Chowchuen B, Sukwanarat Y et al (1995) Effect of Aloe vera gel to healing of burn wound a clinical and histologic study. J Med Assoc Thai 78(8):403–409

    CAS  PubMed  Google Scholar 

  73. Wesley J, Christina A, Chidambaranathan N et al (2009) Wound healing activity of the leaves of Tribulus terrestris (Linn) aqueous extract in rats. J Pharm Res 2(5):841–843

    Google Scholar 

  74. Wu F, Bian D, Xia Y et al (2012) Identification of major active ingredients responsible for burn wound healing of Centella asiatica herbs. Evid Based Complement Alternat Med. doi:10.1155/2012/848093

  75. Yaman I, Durmus AS, Ceribasi S et al (2010) Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats. Vet Med 55(12):619–624

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Authors and Affiliations

  1. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Roodabeh Bahramsoltani

  2. Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, 1417653761, Tehran, Iran

    Roodabeh Bahramsoltani, Mohammad Hosein Farzaei & Roja Rahimi

  3. Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mohammad Hosein Farzaei

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  1. Roodabeh Bahramsoltani
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  2. Mohammad Hosein Farzaei
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Correspondence to Roja Rahimi.

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Drs. Bahramsoltani and Farzaei contributed equally to this review.

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Bahramsoltani, R., Farzaei, M.H. & Rahimi, R. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res 306, 601–617 (2014). https://doi.org/10.1007/s00403-014-1474-6

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