Skip to main content

Advertisement

SpringerLink
Log in

Lack of association with TNF-α-308 promoter polymorphism in patients with vitiligo

  • Short Communication
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in which tumor necrosis factor-α (TNF-α), a paracrine inhibitor of melanocytes, is especially important. Several single-nucleotide polymorphisms (SNP) have been identified in the human TNF gene promoter. The polymorphism at position -308 (TNF-308), which involves substituting G for A and designing the AA genotype, leads to a higher rate of TNF gene transcription than the wild-type GG genotype in in vitro expression studies. It has also been linked to increased susceptibility to several chronic metabolic, degenerative, inflammatory and autoimmune diseases. Therefore, we investigated the TNF-α-308 SNP in patients with vitiligo. We examined 61 patients with vitiligo. Healthy age-, ethnically- and sex-matched individuals (n = 123) served as controls. Polymerase chain reaction amplification was used for analysis of the polymorphism at position -308 in promoter of TNF-α gene. We found that the distribution of TNF-α genotypes in vitiligo patients did not differ from that in control subjects (P > 0.05). Moreover, there was no association between TNF-α genotypes and types of vitiligo. In conclusion, we suggest that TNF-α-308 SNP is not a genetic risk factor for vitiligo susceptibility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Arias AI, Giles B, Eiermann TH, Sterry W, Pandey JP (1997) Tumor necrosis factor-alpha gene polymorphism in psoriasis. Exp Clin Immunogenet 14:118–122

    PubMed  CAS  Google Scholar 

  2. Boin F, Zanardini R, Pioli R, Altamura CA, Maes M, Gennarelli M (2001) Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol Psychiatry 6:79–82

    Article  PubMed  CAS  Google Scholar 

  3. Canton I, Akhtar S, Gavalas NG, Gawkrodger DJ, Blomhoff A, Watson PF et al (2005) A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Genes Immun 6:584–587

    Article  PubMed  CAS  Google Scholar 

  4. Carroll MC, Katzman P, Alicot EM et al (1987) Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes. Proc Natl Acad Sci USA 84:8535–8539

    Article  PubMed  CAS  Google Scholar 

  5. Casp CB, She JX, McCormack WT (2002) Genetic association of the catalase gene (CAT) with vitiligo susceptibility. Pigment Cell Res 15:62–66

    Article  PubMed  CAS  Google Scholar 

  6. Cuenca J, Perez CA, Aguirre AJ, Schiattino I, Aguillon JC (2001) Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population. Biol Res 34:237–241

    Article  PubMed  CAS  Google Scholar 

  7. D’Alfonso S, Richiardi PM (1994) A polymorphic variation in a putative regulation box of the TNF-α promoter region. Immunogenetics 39:150–154

    PubMed  CAS  Google Scholar 

  8. Feldmann M, Brennan FM, Maini R (1998) Cytokines in autoimmune disorders. Int Rev Immunol 17:217–228

    PubMed  CAS  Google Scholar 

  9. Gottenberg JE, Busson M, Loiseau P, Dourche M, Cohen-Solal J, Lepage V et al (2004) Association of transforming growth factor β1 and tumor necrosis factor alpha polymorphisms with anti-SSB/La antibody secretion in patients with primary Sjogren’s syndrome. Arthritis Rheum 50:570–580

    Article  PubMed  CAS  Google Scholar 

  10. Grimes PE, Morris R, Avaniss-Aghajani E, Soriano T, Meraz M, Metzger A (2004) Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokines. J Am Acad Dermatol 51:52–61

    Article  PubMed  Google Scholar 

  11. Huang CL, Nordlund JJ, Boissy R (2002) Vitiligo: a manifestation of apoptosis? Am J Clin Dermatol 3:301–308

    Article  PubMed  CAS  Google Scholar 

  12. Itirli G, Pehlivan M, Alper S, Yuksel SE, Onay H, Ozkinay F et al (2005) Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo. J Dermatol Sci 38:225–227

    Article  PubMed  CAS  Google Scholar 

  13. Jin SY, Park HH, Li GZ, Lee HJ, Hong MS, Park HJ et al (2004) Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients. J Dermatol Sci 35:181–186

    Article  PubMed  CAS  Google Scholar 

  14. Jin SY, Park HH, Li GZ, Lee HJ, Hong MS, Hong SJ et al (2004) Association of angiotensin converting enzyme gene I/D polymorphism of vitiligo in Korean population. Pigment Cell Res 17:84–86

    Article  PubMed  CAS  Google Scholar 

  15. Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I, Fabbri P (2002) Vitiligo and epidermal microenvironment: possible involvement of keratinocyte-derived cytokines. Arch Dermatol 138:273–274

    Article  PubMed  Google Scholar 

  16. Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I, Fabiani M et al (2002) New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 15:87–92

    Article  PubMed  CAS  Google Scholar 

  17. Ongenae K, Van Geel N, Naeyaert JM (2003) Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res 16:90–100

    Article  PubMed  Google Scholar 

  18. Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M et al (1993) Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol 23:224–231

    Article  PubMed  CAS  Google Scholar 

  19. Sullivan KE, Wooten C, Schmeckpeper BJ, Goldman D, Petri M (1997) A promoter polymorphism of tumor necrosis factor-α associated with systemic lupus erythematosus in African-Americans. Arthritis Rheum 40:2207–2211

    Article  PubMed  CAS  Google Scholar 

  20. Tobon GJ, Correa PA, Gomez LM, Anaya JM (2005) Lack of association between TNF-308 polymorphism and the clinical and immunological characteristics of systemic lupus erythematosus and primary Sjogren’s syndrome. Clin Exp Rheumatol 23:339–344

    PubMed  CAS  Google Scholar 

  21. Tursen U, Kaya TI, Erdal ME, Derici E, Gunduz O, Ikizoglu G (2002) Association between catechol-O-methyltransferase polymorphism and vitiligo. Arch Dermatol Res 294:143–146

    Article  PubMed  CAS  Google Scholar 

  22. Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB, Duff GW (1993) An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and D2 alleles. J Exp Med 177:557–560

    Article  PubMed  CAS  Google Scholar 

  23. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW (1997) Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 94:3195–3199

    Article  PubMed  CAS  Google Scholar 

  24. Yucesoy B, Vallyathan V, Landsittel DP, Sharp DS, Weston A, Burleson GR et al (2001) Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis. Toxicol Appl Pharmacol 172:75–82

    Article  PubMed  CAS  Google Scholar 

  25. Zhang XJ, Chen JJ, Liu JB (2005) The genetic concept of vitiligo. J Dermatol Sci 39:137–146

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, School of Medicine, Mersin University, 33079, Mersin, Turkey

    Ayca Cordan Yazici, Tamer Irfan Kaya, Guliz Ikizoglu & Umit Tursen

  2. Department of Genetics, School of Medicine, Mersin University, 33079, Mersin, Turkey

    M. Emin Erdal & Kaan Savasoglu

  3. Department of Biostatistics, School of Medicine, Mersin University, 33079, Mersin, Turkey

    Handan Camdeviren

Authors
  1. Ayca Cordan Yazici
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Emin Erdal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tamer Irfan Kaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Guliz Ikizoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kaan Savasoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Handan Camdeviren
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Umit Tursen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ayca Cordan Yazici.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yazici, A.C., Erdal, M.E., Kaya, T.I. et al. Lack of association with TNF-α-308 promoter polymorphism in patients with vitiligo. Arch Dermatol Res 298, 46–49 (2006). https://doi.org/10.1007/s00403-006-0664-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-006-0664-2

Keywords

Search

Navigation