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Histology can be predictive of the clinical course of a primary aneurysmal bone cyst

  • Orthopaedic Surgery
  • Published:
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Abstract

Introduction

Aneurysmal bone cyst is a benign lesion occurring in young patients which frequently recurs after treatment. Biopsy is mandatory for the diagnosis of a putative aneurysmal bone cyst as this lesion can be secondary to another underlying process including a malignant bone tumour. The histopathological features of aneurysmal bone cysts have been examined with the goal of finding relevant criteria for predicting favourable evolution or recurrence of the disease.

Patients and methods

Twenty-one biopsies of surgically treated aneurysmal bone cysts, from 21 patients, were analysed. Histomorphometry by two different methods (3,000- and 200-point-counting) and by two observers was performed to quantify the percentage of each tissue type in the cyst (cellular, fibrillar, osteoid). A healing index was developed by calculating a ratio of osteoid and fibrillar material divided by cellular tissue. Biopsies were also examined using two immunostains, cluster of differentiation 68 (CD68) and proliferating cell nuclear antigen (PCNA).

Results

The final outcome was healing for 16 aneurysmal bone cysts (healing group) and recurrence for the five others (recurrence group), after a mean follow-up of 4.43 years. The two groups differed significantly in the proportion of their cellular content and their healing index. The ratio of CD68 negative to CD68 positive cells was also significantly different between the two groups.

Conclusion

Biopsy should be considered as a helpful prognostic factor for aneurysmal bone cyst.

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Conflict of interest statement

No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Saint-Luc University Hospital, Université Catholique de Louvain, 10, Avenue Hippocrate, 1200, Brussels, Belgium

    Pierre-Louis Docquier & Christian Delloye

  2. Department of Pathology, Saint-Luc University Hospital, Université Catholique de Louvain, 10, Avenue Hippocrate, 1200, Brussels, Belgium

    Christine Galant

  3. Department of Orthopaedic Surgery, Cliniques Universitaires Saint-Luc, 10, Avenue Hippocrate, 1200, Brussels, Belgium

    Pierre-Louis Docquier

Authors
  1. Pierre-Louis Docquier
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  2. Christian Delloye
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  3. Christine Galant
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Correspondence to Pierre-Louis Docquier.

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Docquier, PL., Delloye, C. & Galant, C. Histology can be predictive of the clinical course of a primary aneurysmal bone cyst. Arch Orthop Trauma Surg 130, 481–487 (2010). https://doi.org/10.1007/s00402-009-0887-8

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  • DOI: https://doi.org/10.1007/s00402-009-0887-8

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