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Benefit of a 17-year long-term bisphosphonate therapy in a patient with Gorham–Stout syndrome

  • Orthopaedic Outcome Assessment
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Abstract

This case report of a 61-year-old woman suffering from Gorham–Stout syndrome shows osteolyses of the left pelvis, proximal femur and lumbar spine. The therapeutic regime has included two courses of percutaneous radiotherapy and also continuous application of bisphosphonates over 17 years. Despite this antiresorptive therapy, elevated urinary excretion of desoxypyridinoline has indicated the persistence of increased bone destruction. The radiological progression following bisphosphonate treatment was only moderate. However, physical disability is reduced, but without soaring handicaps suggesting that long-term bisphophonate therapy is a therapeutical option for this rare syndrome.

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Authors and Affiliations

  1. Department of Internal Medicine III, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany

    Gabriele Lehmann, Gert Hein & Gunter Wolf

  2. Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University, Jena, Germany

    Alexander Pfeil & Werner A. Kaiser

  3. Institute of Diagnostic and Interventional Radiology, SRH Wald-Klinikum Gera, Gera, Germany

    Joachim Böttcher

  4. Department of Radiooncology, Friedrich Schiller University, Jena, Germany

    Jürgen Füller

Authors
  1. Gabriele Lehmann
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  2. Alexander Pfeil
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  3. Joachim Böttcher
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  4. Werner A. Kaiser
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  5. Jürgen Füller
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  6. Gert Hein
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  7. Gunter Wolf
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Correspondence to Gabriele Lehmann.

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Lehmann, G., Pfeil, A., Böttcher, J. et al. Benefit of a 17-year long-term bisphosphonate therapy in a patient with Gorham–Stout syndrome. Arch Orthop Trauma Surg 129, 967–972 (2009). https://doi.org/10.1007/s00402-008-0742-3

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  • DOI: https://doi.org/10.1007/s00402-008-0742-3

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