Skip to main content

Advertisement

SpringerLink
Log in

Radiation-induced meningiomas: clinical, cytogenetic, and microarray features

  • Original Paper
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Abstract

Limited information exists about the clinical and biological features of radiation-induced meningiomas (RIMs), particularly those that follow high-dose therapeutic radiation. We report our experience with 20 patients with RIMs (16 following high-dose radiotherapy) treated at our institution from 1993–2006. Patients (14 female, 6 male) had intervals from first radiotherapy to RIM diagnosis of 11–63 years; 12 had at least one RIM occur at an interval of 30 years or more after initial radiotherapy. Multiple RIMs were seen in six patients, with one patient developing his six RIMs sequentially over a 22-year interval. Most RIMs could be managed surgically, either with a single extensive resection or additional resection(s). Adjuvant stereotactic radiosurgery, external beam radiation, or chemotherapy were required in a minority (n = 6). Most were WHO grade I meningiomas. Complex karyotypes were found in three of four cases and abnormalities of chromosome 1p and/or LOH 1p36 were identified in five of 11 informative cases. Gene-expression microarray analysis of RIMs (n = 5) compared to non-RIMs (MEN, n = 6) and a panel of other tumors (n = 62) showed that RIM gene-expression was similar to that seen in MEN, and by clustering analysis did not separate from them. However, microarray comparative gene-expression analysis did demonstrate a few genes with significant differences in the expression level in RIM versus MEN. Of note, NF2 was under-expressed in four of five RIMs (P = 0.0065), at a similar level as measured in MEN.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Addo-Yobo SO, Straessle J, Anwar A, Donson AM, Kleinschmidt-DeMasters BK, Foreman NK (2006) Paired overexpression of ErbB3 and Sox 10 in pilocytic astrocytoma. J Neuropathol Exp Neurol 65:769–775. doi:10.1097/01.jnen.0000229989.25171.aa

    Article  PubMed  CAS  Google Scholar 

  2. Al-Mefty O, Topsakal C, Pravdenkova S, Sawyer JR, Harrison MJ (2004) Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics. J Neurosurg 100:1002–1013

    PubMed  Google Scholar 

  3. Andreassen CN, Alsner J, Overgaard M, Overgaard J (2003) Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol 69:127–135. doi:10.1016/j.radonc.2003.09.010

    Article  PubMed  CAS  Google Scholar 

  4. Begnami MD, Rushing EJ, Santi M, Quezado M (2007) Evaluation of NF2 gene deletion in pediatric meningiomas using chromogenic in situ hybridization. Int J Surg Pathol 15:110–115. doi:10.1177/1066896906299128

    Article  PubMed  CAS  Google Scholar 

  5. Choudhary A, Pradhan S, Huda MF, Mohanty S, Kumar M (2005) Radiation induced meningioma with a short latent period following high dose cranial irradiation—case report and literature review. J Neurooncol 10:11060–11065

    Google Scholar 

  6. Donson AM, Erwin NS, Kleinschmidt-DeMasters BK, Madden JR, Addo-Yobo SO, Foreman NK (2007) Unique molecular characteristics of radiation-induced glioblastoma. J Neuropathol Exp Neurol 66:740–749. doi:10.1097/nen.0b013e3181257190

    Article  PubMed  CAS  Google Scholar 

  7. Green S, Nair N, Ojemann JG, Avellino AM (2008) Meningiomas in children. Pediatr Neurosurg 44:9–13. doi:10.1159/000110656

    Article  Google Scholar 

  8. Joachim T, Ram Z, Rappaport ZH, Simon M, Schramm J, Wiestler OD et al (2001) Comparative analysis of the NF2, TP53, PTEN, KRAS, NRAS and HRAS genes in sporadic and radiation-induced human meningiomas. Int J Cancer 94:218–221. doi:10.1002/ijc.1467

    Article  PubMed  CAS  Google Scholar 

  9. Kleinschmidt-DeMasters BK, Kang JS, Lillehei KO (2006) The burden of radiation-induced central nervous system tumors: a single institution’s experience. J Neuropathol Exp Neurol 65:204–216

    PubMed  CAS  Google Scholar 

  10. Kleinschmidt-DeMasters BK, Lillehei KO (1995) Radiation induced meningioma with 63 year latency period. J Neurosurg 82:487–488

    Article  PubMed  CAS  Google Scholar 

  11. Kleinschmidt-DeMasters BK, Meltesen L, McGavran L, Lillehei KO (2006) Characterization of glioblastomas in young adult patients. Brain Pathol 16:273–286. doi:10.1111/j.1750-3639.2006.00029.x

    Article  PubMed  CAS  Google Scholar 

  12. Lomas J, Bello MJ, Arjona D, Alonso ME, Martinez-Glez V, Lopez-Marin I et al (2005) Genetic and epigenetic alteration of the NF2 gene in sporadic meningiomas. Genes Chromosomes Cancer 42:314–319. doi:10.1002/gcc.20141

    Article  PubMed  CAS  Google Scholar 

  13. Murakami M, Hashimoto N, Takahashi Y, Hosokawa Y, Inazawa J, Mineura K (2003) A consistent region of deletion on 1p36 in meningiomas: identification and relation to malignant progression. Cancer Genet Cytogenet 140:99–106. doi:10.1016/S0165-4608(02)00653-2

    Article  PubMed  CAS  Google Scholar 

  14. Musa BS, Pople IK, Cummins BH (1995) Intracranial meningiomas following irradiation—a growing problem? Br J Neurosurg 9:629–637. doi:10.1080/02688699550040918

    Article  PubMed  CAS  Google Scholar 

  15. Pagni CA, Canavero S, Fiocchi F, Ponzio G (1993) Chromosome 22 monosomy in a radiation-induced meningioma. Ital J Neurol Sci 14:377–379

    PubMed  CAS  Google Scholar 

  16. Perry A, Louis DN, Budka Scheithauer BW, von Deimling A (2007) Meningiomas. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system. IARC Press, Lyon, pp 164–172

    Google Scholar 

  17. Pfisterer WK, Hank NC, Preul MC, Hendricks WP, Pueschel J, Coons SW et al (2004) Diagnostic and prognostic significance of genetic regional heterogeneity in meningiomas. J Neurooncol 6:290–299

    CAS  Google Scholar 

  18. Pistolesi S, Boldrini L, Gisfredi S, De Ieso K, Camacci T, Caniglia M et al (2004) Immunohistochemical and molecular study of radiation-induced multiple meningiomas with pleural and pulmonary metastasis. Tumori 90:328–332

    PubMed  Google Scholar 

  19. Pollak L, Walach N, Gur R, Schiffer J (1998) Meningiomas after radiotherapy for tinea capitis—still no history. Tumori 84:65–68

    PubMed  CAS  Google Scholar 

  20. Ron E, Modan B, Boice JD Jr, Alfandary E, Stovall M, Chetrit A et al (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319:1033–1039

    PubMed  CAS  Google Scholar 

  21. Rubinstein AB, Shalit MN, Cohen ML, Zandbank U, Reichenthal E (1984) Radiation-induced cerebral meningioma: a recognizable entity. J Neurosurg 61:966–971

    PubMed  CAS  Google Scholar 

  22. Sadetzki S, Flint-Richter P, Ben-Tal T, Nass D (2002) Radiation-induced meningioma: a descriptive study of 253 cases. J Neurosurg 97:1078–1082

    Article  PubMed  Google Scholar 

  23. Sadetzki S, Flint-Richter P, Starinsky S, Novikov I, Lerman Y, Goldman B et al (2005) Genotyping of patients with sporadic and radiation-associated meningiomas. Cancer Epidemiol Biomarkers Prev 14:969–976. doi:10.1158/1055-9965.EPI-04-0366

    Article  PubMed  CAS  Google Scholar 

  24. Sadetzki S, Modan B, Chetrit A, Freedman L (2000) An iatrogenic epidemic of benign meningioma. Am J Epidemiol 151:266–272

    PubMed  CAS  Google Scholar 

  25. Shoshan Y, Chernova O, Jeun S, Somerville RP, Israel Z, Barnett GH et al (2000) Radiation-induced meningioma: a distinct molecular genetic pattern? J Neuropathol Exp Neurol 59:614–620

    PubMed  CAS  Google Scholar 

  26. Yilmaz Z, Sahin FI, Atalay B, Ozen O, Caner H, Bavbek M et al (2005) Chromosome 1p36 and 22qter deletions in paraffin block sections of intracranial meningiomas. Pathol Oncol Res 11:224–228

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank Ms. Lisa Litzenberger for expert photographic expertise, Mrs. Diane Hutchinson for manuscript preparation, and Mr. Colin Catel for data assistance. This study was supported in part by funds from the Michelle Plachy-Rubin Brain Tumor Grant to the Department of Neurosurgery, University of Colorado Health Sciences Center and from the Morgan Adams Foundation.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Colorado at Denver Health Sciences Center, Aurora, CO, USA

    Kevin O. Lillehei & B. K. Kleinschmidt-DeMasters

  2. Department of Pathology, University of Colorado at Denver Health Sciences Center, Aurora, CO, USA

    B. K. Kleinschmidt-DeMasters

  3. Department of Neurology, University of Colorado at Denver Health Sciences Center, Aurora, CO, USA

    B. K. Kleinschmidt-DeMasters

  4. Department of Pediatrics, University of Colorado at Denver Health Sciences Center, Aurora, CO, USA

    Andrew M. Donson

  5. Department of Surgical Pathology, UCDHSC, Mail Stop B216, 12631 E. 17th Avenue, P O. Box 6511, Aurora, CO, 80045, USA

    B. K. Kleinschmidt-DeMasters

Authors
  1. Kevin O. Lillehei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrew M. Donson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. K. Kleinschmidt-DeMasters
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. K. Kleinschmidt-DeMasters.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lillehei, K.O., Donson, A.M. & Kleinschmidt-DeMasters, B.K. Radiation-induced meningiomas: clinical, cytogenetic, and microarray features. Acta Neuropathol 116, 289–301 (2008). https://doi.org/10.1007/s00401-008-0401-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-008-0401-3

Keywords

Search

Navigation