Abstract
We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson’s disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with α-synuclein immunohistochemistry, and we divided the neurons into three subtypes according to differences in α-synuclein immunoreactivity: (1) neurons without pale bodies or Lewy bodies, (2) neurons with pale bodies, and (3) neurons with Lewy bodies. In controls, we did not observe fragmented GA in nigral neurons by immunocytochemistry with an anti-TGN46 antibody. In PD, the GA was fragmented in 3% of the nigral neurons without inclusions, and in 5% of the neurons with Lewy bodies. In contrast, fragmented GA was noted in 19% of the neurons containing pale bodies. Since pale bodies represent early stages in the development of brainstem Lewy bodies, our results suggest that the cytotoxicity of α-synuclein-positive aggregates is reduced in the process of Lewy body formation.
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Acknowledgments
We are very much grateful to Professor Gonatas NK for donating the anti-MG160 antibody. This work was supported by a grant from the Ministry of Health, Labour and Welfare in Japan to K. Okamoto.
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Fujita, Y., Ohama, E., Takatama, M. et al. Fragmentation of Golgi apparatus of nigral neurons with α-synuclein-positive inclusions in patients with Parkinson’s disease. Acta Neuropathol 112, 261–265 (2006). https://doi.org/10.1007/s00401-006-0114-4
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DOI: https://doi.org/10.1007/s00401-006-0114-4