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P25α immunoreactivity in multiple system atrophy and Parkinson disease

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References

  1. Baker KG, Huang Y, McCann H, Gai WP, Jensen PH, Halliday GM (2006) P25alpha immunoreactive but alpha-synuclein immunonegative neuronal inclusions in multiple system atrophy. Acta Neuropathol (Berl) 111:193–195

    Article  Google Scholar 

  2. Galpern WR, Lang AE (2006) Interface between tauopathies and synucleinopathies: a tale of two proteins. Ann Neurol 59:449–458

    Article  PubMed  CAS  Google Scholar 

  3. Kovacs GG, Laszlo L, Kovacs J, Jensen PH, Lindersson E, Botond G, Molnar T, Perczel A, Hudecz F, Mezo G, Erdei A, Tirian L, Lehotzky A, Gelpi E, Budka H, Ovadi J (2004) Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Neurobiol Dis 17:155–162

    Article  PubMed  CAS  Google Scholar 

  4. Lindersson E, Beedholm R, Hojrup P, Moos T, Gai W, Hendil KB, Jensen PH (2004) Proteasomal inhibition by alpha-synuclein filaments and oligomers. J Biol Chem 279:12924–12934

    Article  PubMed  CAS  Google Scholar 

  5. Otzen DE, Lundvig DM, Wimmer R, Nielsen LH, Pedersen JR, Jensen PH (2005) p25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry. Protein Sci 14:1396–1409

    Article  PubMed  CAS  Google Scholar 

  6. Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson’s disease and dementia with Lewy bodies. Neurosci Lett 251:205–208

    Article  PubMed  CAS  Google Scholar 

  7. Wenning GK, Jellinger KA (2005) The role of alpha-synuclein and tau in neurodegenerative movement disorders. Curr Opin Neurol 18:357–362

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria

    Kurt A. Jellinger

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  1. Kurt A. Jellinger
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Correspondence to Kurt A. Jellinger.

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Jellinger, K.A. P25α immunoreactivity in multiple system atrophy and Parkinson disease. Acta Neuropathol 112, 112 (2006). https://doi.org/10.1007/s00401-006-0075-7

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  • DOI: https://doi.org/10.1007/s00401-006-0075-7

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