Abstract
This study attempts to explain the bioavailability, permeability, and interaction parameters of organotin(IV) derivatives with the cell membrane. For this purpose, tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] was synthesized and characterized by elemental analysis and spectroscopic methods (Fourier transform infrared spectroscopy (FT-IR), 1H, 13C, 119Sn NMR). The organic anion was found to act as monodentate O-bound ligand in solution. Cationic surfactant cetyl N,N,N-trimethylammoniumbromide (CTAB) was used to study the interactions of the organotin(IV) complex with positively charged molecules of the surfactant acting as a model cell membrane. The thermodynamic parameters of complex–CTAB interaction concluded that the complex is located in the peripheral region of CTAB micelles. The redshifts in the UV spectra of the complex confirmed its solubilization into micelles. The two carbonyl oxygen atoms were found to be binding sites of the complex with CTAB.
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Shah, F.A., Khan, A.M., Sabir, S. et al. CTAB–tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] interaction: a tool for predicting organotin(IV) complex–cell membrane interaction parameters. Colloid Polym Sci 294, 87–94 (2016). https://doi.org/10.1007/s00396-015-3738-x
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DOI: https://doi.org/10.1007/s00396-015-3738-x