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Synthesis of cross-linked poly (N-isopropylacrylamide) microparticles in supercritical carbon dioxide

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Abstract

Herein, we report a new method that has been developed to prepare thermoresponsive polymers. The white, dry, fine powders were obtained directly from cross-linking polymerization of N-isopropylacrylamide in supercritical carbon dioxide (scCO2) with N,N-methylenebisacrylamide as a cross-linker. The effects of the reaction pressure and time as well as the initial concentrations of the initiator, cross-linker, and monomer on the yield and morphology of the resulting polymer were investigated systematically. The polymer yield was increased with the concentrations of the cross-linker, monomer, and reaction time. Under the condition of using higher cross-linker concentrations, the cross-linked poly (N-isopropylacrylamide) microparticles with diameters of 50 nm were generated in scCO2 in high-yield and short reaction times. These results suggest that the synthetic method using scCO2 can be used to prepare biomedical materials such as the controlled drug-release system.

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Acknowledgment

Support from the National Natural Science Foundation of China (20674098) is gratefully acknowledged.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, People’s Republic of China

    Li-qin Cao, Liu-ping Chen, Ji-qing Jiao, Shu-ying Zhang & Wei Gao

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  1. Li-qin Cao
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  2. Liu-ping Chen
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  3. Ji-qing Jiao
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  4. Shu-ying Zhang
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  5. Wei Gao
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Correspondence to Liu-ping Chen.

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Cao, Lq., Chen, Lp., Jiao, Jq. et al. Synthesis of cross-linked poly (N-isopropylacrylamide) microparticles in supercritical carbon dioxide. Colloid Polym Sci 285, 1229–1236 (2007). https://doi.org/10.1007/s00396-007-1675-z

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  • DOI: https://doi.org/10.1007/s00396-007-1675-z

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