Abstract
Background
Vitamin D deficiency is associated with glycemic dysregulation in many observational studies. However, the causality between them has not been fully established, especially in Asian origin. We used bidirectional Mendelian randomization (MR) analysis to explore the causal relationship between 25-hydroxyvitamin D [25(OH)D] and glycemic status and indices.
Methods
Participants were included from a survey in East China from 2014 to 2016 (10,338 and 10,655 participants having diabetes and vitamin D-related genotyping information). We calculated weighted genetic risk scores (GRS) as the instrumental variables for 25(OH)D concentration and diabetes based on related single nucleotide polymorphisms. Diagnosis of type 2 diabetes and prediabetes was based on American Diabetes Association criteria.
Results
The MR-derived odds ratios of genetically determined 25(OH)D for risk of type 2 diabetes (1565/10655) and prediabetes (3915/10655) was 0.985 (95% CI 0.940, 1.032) and 0.982 (95% CI 0.948, 1.016), respectively. The MR-derived estimates for fasting plasma glucose and HbA1c were also not significant. Moreover, the MR-derived regression coefficients of genetically determined diabetes and prediabetes for 25(OH)D was 0.448 (95% CI − 0.395, 1.291) and 1.303 (95% CI − 1.210, 3.816).
Conclusions
Our results support the conclusion that there is no causal association between vitamin D and type 2 diabetes and prediabetes using a bidirectional MR approach in a Chinese population.
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Acknowledgements
YL and NW designed research; NW, CW, XC, HW, YC, CC and BH conducted research; NW and CW analyzed data; and NW, CW and YL wrote the paper. YL had primary responsibility for the final content. All authors read and approved the final manuscript. The authors thank Xiaojin Wang and Bingshun Wang from the Department of Biostatistics and Shanghai Jiaotong University School of Medicine for data processing. The authors thank Weiping Tu, Bin Li and Ling Hu for help in organize this investigation. The authors thank all team members and participants in the SPECT-China study.
Funding
This study was supported by the National Natural Science Foundation of China (81570726, 81600609); Shanghai JiaoTong University School of Medicine (2014); Science and Technology Commission of Shanghai Municipality (16411971200, 16410723200); Commission of Health and Family Planning of Pudong District (PW2015D-5); the Fourth Round of Three-Year Public Health Action Plan of Shanghai by the Shanghai Municipal Commission of Health and Family Planning (15GWZK0202, 20164Y0079); Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ053); and Clinical Research Plan of SHDC (16CR3076B). The funders played no role in the design or conduct of the study, collection, management, analysis, or interpretation of data or in the preparation, review, or approval of the article.
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The abstract of the paper has already been published in Diabetes 2018 Jul 67(Supplement 1): https://doi.org/10.2337/db18-1602-P.
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Wang, N., Wang, C., Chen, X. et al. Vitamin D, prediabetes and type 2 diabetes: bidirectional Mendelian randomization analysis. Eur J Nutr 59, 1379–1388 (2020). https://doi.org/10.1007/s00394-019-01990-x
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DOI: https://doi.org/10.1007/s00394-019-01990-x