Abstract
Purpose
Gene-dietary patterns may contribute to determining body composition and related biochemical indices. The aim of this study was to evaluate interactions between rs1333048 polymorphism and major dietary patterns on body fat percentage, general and central obesity, and related biochemical measurements.
Methods
This cross-sectional study was conducted on 265 healthy Tehrani adults with mean age of 35 years (47.5% men, 52.5% women). Dietary patterns (DPs) were extracted by factor analysis. Bioelectrical impedance analysis was used for body analysis and rs1333048 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method.
Results
Three DPs were extracted: restricted refined grains DP, legumes DP and healthy DP. AA genotype compared to CC genotype had greater odds for general obesity before (OR 3.14; 95% CI 1.008–9.60, P = 0.045) and after (OR 3.11; 95% CI 1.008–9.60, P = 0.048) adjusting for potential confounders. Individuals with AA genotype were more likely to be centrally obese before (OR 2.09; 95% CI 1.006–4.35, P = 0.048) and after (OR 2.63; 95% CI 1.12–6.17, P = 0.026) controlling for potential confounders. Significant interactions were observed between Legumes DP and rs1333048 SNP on waist circumference (P = 0.047), body fat % (BFP) (P = 0.048), hs-Crp (P = 0.042), BMI (P = 0.073), WHtR (P = 0.063) and odds for general obesity (P = 0.051). Following this DP reduced all these items for individuals with CC genotype, whereas increased them for people who carry CA or AA genotypes.
Conclusions
The findings indicate that there are significant associations between AA genotype of rs1333048 SNP and general and central obesity, and significant interaction between alleles of this SNP and major dietary patterns on the odds of general obesity, BFP, waist circumference, BMI, WHtR and hs-Crp.
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Abbreviations
- ADIPOQ:
-
Adiponectin gene
- ALT:
-
Alanine aminotransferase
- APOB:
-
Apolipoprotein B
- AST:
-
Aspartate aminotransferase
- BFP:
-
Body fat percentage
- BIA:
-
Bioelectrical impedance analysis
- BMI:
-
Body mass index
- bp:
-
Base pair
- CAD:
-
Coronary artery disease
- CDKN2B:
-
Cyclin-dependent kinase inhibitor 2B
- DP:
-
Dietary pattern
- CVD:
-
Cardiovascular disease
- DNA:
-
Deoxyribonucleic acid
- FBS:
-
Fasting blood sugar
- FFM:
-
Fat-free mass
- FFQ:
-
Food frequency questionnaire
- FM:
-
Fat mass
- FTO:
-
Fat mass and obesity associated gene
- GLM:
-
General linear model
- GWAS:
-
Genome-wide association studies
- HDL:
-
High-density lipoprotein cholesterol
- HDP:
-
Healthy dietary pattern
- hs-Crp:
-
High sensitivity C-reactive protein
- IPAQ:
-
International Physical Activity Questionnaire
- LDL:
-
Low-density lipoprotein
- LDLR:
-
Low-density lipoprotein receptor
- LDP:
-
Legumes dietary pattern
- MC4R:
-
Melanocortin 4 receptor
- MET-h/wk:
-
Metabolic equivalent hours per week
- MI:
-
Myocardial infarction
- MYH7:
-
Myosin heavy chain 7
- PCR:
-
Polymerase chain reaction
- qPCR:
-
Quantitative polymerase chain reaction
- RFLP:
-
Restriction fragment length polymorphism
- RRGDP:
-
Restricted refined grains dietary pattern
- SAT:
-
Subcutaneous adipose tissue
- SNP:
-
Single nucleotide polymorphism
- TC:
-
Total cholesterol
- TG:
-
Triglyceride
- VAT:
-
Visceral adipose tissue
- WC:
-
Waist circumference
- WHtR:
-
Waist-to-height ratio
- WHO:
-
World Health Organization
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Acknowledgements
We are thankful to all participants who took part in the study. This study was supported by a Grant from Tehran University of Medical Sciences (Grant ID: 93-04-161-27722).
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Mollahosseini, M., Rahimi, M.H., Yekaninejad, M.S. et al. Dietary patterns interact with chromosome 9p21 rs1333048 polymorphism on the risk of obesity and cardiovascular risk factors in apparently healthy Tehrani adults. Eur J Nutr 59, 35–43 (2020). https://doi.org/10.1007/s00394-018-1872-1
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DOI: https://doi.org/10.1007/s00394-018-1872-1