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Put “gender glasses” on the effects of phenolic compounds on cardiovascular function and diseases

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Abstract

Introduction

The influence of sex and gender is particularly relevant in cardiovascular diseases (CVD) as well as in several aspects of drug pharmacodynamics and pharmacokinetics. Anatomical and physiological differences between the sexes may influence the activity of many drugs, including the possibility of their interaction with other drugs, bioactive compounds, foods and beverages. Phenolic compounds could interact with our organism at organ, cellular, and molecular levels triggering a preventive action against chronic diseases, including CVD.

Results

This article will review the role of sex on the activity of these bioactive molecules, considering the existence of sex differences in oxidative stress. It describes the pharmacokinetics of phenolic compounds, their effects on vessels, on cardiovascular system, and during development, including the role of nuclear receptors and microbiota.

Conclusions

Although there is a large gap between the knowledge of the sex differences in the phenolic compounds’ activity and safety, and the urgent need for more research, available data underlie the possibility that plant-derived phenolic compounds could differently influence the health of male and female subjects.

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Acknowledgements

This research was partially funded by a Grant of INAIL “Bando BRIC 2016”.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Via Muroni 23, University of Sassari, Sassari, Italy

    Ilaria Campesi & Flavia Franconi

  2. Laboratory of Sex-Gender Medicine, National Institute of Biostructures and Biosystems, Sassari, Italy

    Ilaria Campesi & Flavia Franconi

  3. Department of Science, University Roma Tre, Rome, Italy

    Maria Marino & Manuela Cipolletti

  4. Laboratorio PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement Technology and Analysis), University of Florence, Sesto F.no, Firenze, Italy

    Annalisa Romani

  5. Assessorato alle Politiche per la Persona of Basilicata Region, Potenza, Italy

    Flavia Franconi

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  1. Ilaria Campesi
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  2. Maria Marino
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  3. Manuela Cipolletti
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  4. Annalisa Romani
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  5. Flavia Franconi
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Correspondence to Ilaria Campesi.

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Campesi, I., Marino, M., Cipolletti, M. et al. Put “gender glasses” on the effects of phenolic compounds on cardiovascular function and diseases. Eur J Nutr 57, 2677–2691 (2018). https://doi.org/10.1007/s00394-018-1695-0

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  • DOI: https://doi.org/10.1007/s00394-018-1695-0

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