Zusammenfassung
Das Immunsystem wird von verschiedenen Mechanismen reguliert, die ein Entgleisen der Immunantwort und einen Bruch der Toleranz verhindern. Seit einiger Zeit gibt es Hinweise, dass auch B-Zellen ein Teil dieses Netzwerks sind und regulatorische Aufgaben übernehmen können. Der vorliegende Artikel beschreibt die bisherigen Erkenntnisse zu dieser vormals unbeachteten Funktion von B-Zellen und ihre potenzielle Bedeutung im Schutz vor Autoimmunität.
Abstract
The immune system is regulated by a variety of mechanisms that prevent overwhelming immune responses and a break in tolerance. There have been indications for some time that populations of B cells are also a part of this network and able to exert regulatory functions. Here we summarize current knowledge on this previously unrecognized B cell function and their potential role in protection against autoimmunity.
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Literatur
Blair PA, Norena LY, Flores-Borja F et al (2010) CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 32:129–140
Bouaziz JD, Yanaba K, Tedder TF (2008) Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev 224:201–214
Fillatreau S, Gray D, Anderton SM (2008) Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol 8:391–397
Fillatreau S, Sweenie CH, Mcgeachy MJ et al (2002) B cells regulate autoimmunity by provision of IL-10. Nat Immunol 3:944–950
Frommer F, Heinen TJ, Wunderlich FT et al (2008) Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol 181:5748–5759
Jahrsdorfer B, Blackwell SE, Wooldridge JE et al (2006) B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation. Blood 108:2712–2719
Lampropoulou V, Calderon-Gomez E, Roch T et al (2010) Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity. Immunol Rev 233:146–161
Lundy SK (2009) Killer B lymphocytes: the evidence and the potential. Inflamm Res [Epub ahead of print Mar 5]
Martin F, Chan AC (2004) Pathogenic roles of B cells in human autoimmunity; insights from the clinic. Immunity 20:517–527
Mauri C, Gray D, Mushtaq N et al (2003) Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 197:489–501
Tian J, Zekzer D, Hanssen L et al (2001) Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol 167:1081–1089
Tretter T, Venigalla RK, Eckstein V et al (2008) Induction of CD4+ T-cell anergy and apoptosis by activated human B cells. Blood 112:4555–4564
Van Amelsfort JM, Van Roon JA, Noordegraaf M et al (2007) Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 56:732–742
Wolf SD, Dittel BN, Hardardottir F et al (1996) Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 184:2271–2278
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Die korrespondierende Autorin weist auf folgende Beziehung hin: Vortragstätigkeit für die Firma Roche.
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Tretter, T., Lorenz, HM. Regulatorische B-Zellen und ihre Funktion im Erhalt der peripheren Toleranz. Z. Rheumatol. 69, 813–817 (2010). https://doi.org/10.1007/s00393-010-0713-2
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DOI: https://doi.org/10.1007/s00393-010-0713-2