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Therapie der pulmonalen arteriellen Hypertonie (PAH) mit dem oralen Endothelin-Rezeptor Antagonisten Bosentan bei systemischer Sklerose: Die BREATHE-1-Studie und klinische Erfahrungen

Treatment of pulmonary arterial hypertension (PAH) with oral endothelin-receptor antagonist bosentan in systemic sclerosis: BREATHE-1 trial and clinical experience

  • KLINISCHE STUDIEN KURZGEFASST
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References

  1. Ahmadi-Simab K, Lamprecht P, Gross WL (2003) Erfolgreiche Therapie der Kollagenose-assoziierten pulmonalarteriellen Hypertonie (PAH) unter Bosentan (Abstract). Endothelinantagonisten-Symposium. Essen, 11. 10. 2003

  2. Channick R, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF, Badesch DB, Roux S, Rainisio M, Bodin F, Rubin LJ (2001) Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo controlled study. Lancet 358:1119–1123

    Article  CAS  PubMed  Google Scholar 

  3. D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT (1991) Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115:343–349

    CAS  PubMed  Google Scholar 

  4. McLaughlin V, Sitbon O, Rubin LJ (2003) The effect of first-line bosentan on survival of patients with primary pulmonary hypertension (Abstract). Meeting of the American Thoracic Society, 19. 5. 2003

    Google Scholar 

  5. Rubin LJ, Badesch DB, Barst RJ, Galie N, Black CM, Keogh A, Pulido T, Frost A, Roux S, Leconte I, Landzberg M, Simonneau G (2002) Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 346:896–903

    Article  CAS  PubMed  Google Scholar 

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Ahmadi-Simab, K., Lamprecht, P., Hellmisch, B. et al. Therapie der pulmonalen arteriellen Hypertonie (PAH) mit dem oralen Endothelin-Rezeptor Antagonisten Bosentan bei systemischer Sklerose: Die BREATHE-1-Studie und klinische Erfahrungen. Z Rheumatol 63, 495–497 (2004). https://doi.org/10.1007/s00393-004-0594-3

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  • DOI: https://doi.org/10.1007/s00393-004-0594-3

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