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Prenatal diagnosis at different gestational times and clinical features of choledochal cysts: a single tertiary center report

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Abstract

Purpose

This study aimed to evaluate the effect of prenatal diagnosis at different gestational times on the clinical features of patients with choledochal cysts (CDCs).

Methods

Medical records of patients with prenatally diagnosed CDCs admitted to our hospital (April 2013–April 2018) were retrospectively reviewed. The clinical characteristics and pathological CDC features were analyzed.

Results

Two hundred eighteen cases were included. Patients were divided into two groups. Group 1 and group 2 had a prenatal diagnosis at ≤ 27 weeks of gestation (second trimester of gestation, n = 157) and > 27 weeks (third trimester of gestation, n = 61), respectively. The incidence of jaundice and the TBIL, IBIL and GGT levels were higher in Group 1 (P = 0.021, P = 0.029, P = 0.042, P = 0.007, respectively). The maximum cyst diameter at the time of surgery was larger in Group 1 (P = 0.015). An association study showed that the time of prenatal diagnosis was negatively correlated with the maximum cyst diameter both postnatally (r = − 0.223, P = 0.001) and at the time of surgery (r = − 0.268, P < 0.001).

Conclusion

Unlike patients diagnosed at a late prenatal age, patients diagnosed at an early prenatal age tend to present clinical symptoms (jaundice, manifested as high indirect bilirubin), hepatic function damage, and large cysts at the time of surgery.

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Abbreviations

CDC:

Choledochal cyst

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Funding

The project is supported by Research Unit of Minimally Invasive Pediatric Surgery on Diagnosis and Treatment, Chinese Academy of Medical Sciences 2021RU015. No. 2021-I2M-5-016.

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Authors and Affiliations

  1. Children’s Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Dan Yang, Long Li, Mei Diao, Xianghui Xie, Anxiao Ming, Yu Tian & Ruyue Gao

  2. Beijing Tsinghua Changgung Hospital, Beijing, China

    Anxiao Ming

Authors
  1. Dan Yang
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  2. Long Li
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  3. Mei Diao
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  4. Xianghui Xie
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  6. Yu Tian
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  7. Ruyue Gao
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Contributions

Conception and design: Long Li, Mei Diao, Anxiao Ming, Dan Yang; Analysis and interpretation of data: Yu Tian, Ruyue Gao, Dan Yang; Drafting of the manuscript: Dan Yang; Critical revision of the manuscript for important intellectual content: Long Li, Mei Diao, Xianghui Xie; All authors have read and approved the manuscript.

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Correspondence to Long Li.

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Yang, D., Li, L., Diao, M. et al. Prenatal diagnosis at different gestational times and clinical features of choledochal cysts: a single tertiary center report. Pediatr Surg Int 39, 105 (2023). https://doi.org/10.1007/s00383-023-05374-5

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  • DOI: https://doi.org/10.1007/s00383-023-05374-5

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