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Portosystemic shunt for portal hypertension after Kasai operation in patients with biliary atresia

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Abstract

Purpose

Many biliary atresia (BA) patients will eventually develop liver failure even after a successful Kasai portoenterostomy. A common complication of long-term BA survivors with their native liver is problematic portal hypertension. The aim of this study was to defend the view that portosystemic shunts can delay or negate the need for transplantation in these children.

Methods

A retrospective single center review of the efficacy of portosystemic shunts in BA patients after a successful Kasai portoenterostomy was conducted.

Results

From 1991 to 2017, 11 patients received portosystemic shunts. Median age of Kasai operation was 48 (36–61) days. Shunts were performed at the median age of 6.2 (4.1–6.8) years. Three of these eleven patients required subsequent liver transplantation. OS at 5 and 10 years were 90.9% and 81.8%, respectively. TFS at 5 and 10 years were 90.9% and 72.7%, respectively. Long-term complications included mild encephalopathy in 2 patients, hypersplenism in 3, and cholestasis in 1.

Conclusion

Portosystemic shunt for the treatment of portal hypertension in carefully selected BA patients is an effective option in delaying or negating the need for liver transplantation.

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Authors and Affiliations

  1. Children’s Hospital at Westmead, Sydney, Australia

    Toru Shimizu, Albert Shun & Gordon Thomas

  2. Nagano Children’s Hospital, Nagano, Japan

    Toru Shimizu

Authors
  1. Toru Shimizu
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  2. Albert Shun
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  3. Gordon Thomas
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Correspondence to Toru Shimizu.

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This article does not contain any studies with animals performed by any of the authors.

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This study was approved by the hospital’s ethical board (HREC reference number: LNR/15/SCHN/307, SSA reference number: LNRSSA/16/SCHN/270).

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The individual written informed consent was waived because of the retrospective design.

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Shimizu, T., Shun, A. & Thomas, G. Portosystemic shunt for portal hypertension after Kasai operation in patients with biliary atresia. Pediatr Surg Int 37, 101–107 (2021). https://doi.org/10.1007/s00383-020-04773-2

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