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Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats

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Abstract

Purpose

Dermal templates, such as Matriderm® and Integra®, are widely used in plastic and reconstructive surgery, often as two-step procedures. A recent development is the application of thin dermal templates covered with split thickness skin grafts in one-step procedures. In this experimental study, we compare the two thin matrices Matriderm® 1 mm and Integra® Single Layer in a one-step procedure with particular focus on neodermis formation.

Methods

Matriderm® 1 mm and Integra® Dermal Regeneration Template—Single Layer (1.3 mm) were compared in a rat model. In three groups of five animals each, a full thickness wound was covered with (a) Matriderm® 1 mm and neonatal rat epidermis, (b) Integra® Single Layer and neonatal rat epidermis, or, (c) neonatal rat epidermis only (control). Histological sections 2 weeks post transplantation were analyzed with regard to take of template and epidermis, neodermal thickness, collagen deposition, vascularization, and inflammatory response.

Results

Take of both templates was complete in all animals. The Matriderm®-based neodermis was thinner but showed a higher cell density than the Integra®-based neodermis. The other parameters were similar in both matrices.

Conclusion

The two templates demonstrate a comparable biological behavior early after transplantation. The only difference was found regarding neodermal thickness, probably resulting from faster degradation of Matriderm®. These preliminary data suggest that both dermal templates appear similarly suitable for transplantation in a one-step procedure.

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Acknowledgments

This work was financially supported by EU-FP6 project EuroSTEC (soft tissue engineering for congenital birth defects in children: contract: LSHB-CT-2006-037409) and by the University of Zurich. We are particularly grateful to the Foundation Gaydoul and the sponsors of “DonaTissue” (Thérèse Meier, Robert Zingg, the Vontobel Foundation, and the Werner Spross Foundation) for their generous financial support and interest in our work.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, Tissue Biology Research Unit, University Children’s Hospital Zurich, Zurich, Switzerland

    Sophie Böttcher-Haberzeth, Thomas Biedermann, Fabienne Hartmann-Fritsch & Ernst Reichmann

  2. Department of Surgery, Pediatric Burn Center, Plastic and Reconstructive Surgery, University Children’s Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland

    Sophie Böttcher-Haberzeth, Clemens Schiestl & Martin Meuli

  3. Department of Surgery, Hospital Frauenfeld, Frauenfeld, Switzerland

    Jörg Schneider

Authors
  1. Sophie Böttcher-Haberzeth
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  2. Thomas Biedermann
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  3. Clemens Schiestl
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  4. Fabienne Hartmann-Fritsch
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  5. Jörg Schneider
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  6. Ernst Reichmann
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  7. Martin Meuli
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Corresponding author

Correspondence to Martin Meuli.

Additional information

S. Böttcher-Haberzeth and T. Biedermann contributed equally to this paper.

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Böttcher-Haberzeth, S., Biedermann, T., Schiestl, C. et al. Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats. Pediatr Surg Int 28, 171–177 (2012). https://doi.org/10.1007/s00383-011-2990-5

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