Skip to main content

Advertisement

SpringerLink
Log in

Intrathyroidal parathyroid carcinoma in a pediatric patient

  • Case Report
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

Parathyroid carcinoma is unusual and its intrathyroidal variant is extremely rare. Therefore, few cases have been reported to describe a case of parathyroid carcinoma located inside the thyroid gland. The case corresponds to a 14-year-old girl who came to the office with a severe osteoarticular disease, depression, calcemia of 14.3 mg/dl and parathyroid hormone of 2,792 pg/ml. Right neck exploration was conducted and a parathyroid carcinoma was found located intrathyroidally. A right thyroid lobectomy was performed. A 20-month follow-up period revealed no recurrence of clinical or biochemical signs. In patients with severe hypercalcemia and significant elevation of parathyroid hormone, the diagnosis of parathyroid carcinoma has to be considered. It is worth highlighting the early age of presentation in this case. Treatment has allowed the effective control of the disease and its recommended long-term follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Wynne AG, van Heerden J, Carney JA, Fitzpatrick LA (1992) Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore) 71(4):197–205

    CAS  Google Scholar 

  2. De Quervain VF (1909) Parastruma maligna aberrata. Deut Zschr Chir 100:334–352

    Article  Google Scholar 

  3. Armstrong HG (1938) Primary carcinoma of the parathyroid with report of a case. Bull Acad M Toronto 11:105–110

    Google Scholar 

  4. Kirstein LJ, Ghosh BC (2001) Intrathyroid parathyroid carcinoma. J Surg Oncol 77(2):136–138

    Article  PubMed  CAS  Google Scholar 

  5. Crescenzo DG, Shabahang M, Garvin D, Evans SR (1998) Intrathyroidal parathyroid cancer presenting as a left neck mass. Thyroid 8(7):597–599

    Article  PubMed  CAS  Google Scholar 

  6. Schmidt JL, Perry RC, Philippsen LP, Wu HH (2002) Intrathyroidal parathyroid carcinoma presenting with only hypercalcemia. Otolaryngol Head Neck Surg 127(4):352–353

    Article  PubMed  Google Scholar 

  7. Hussein WI, El-Maghraby TA, Al-Sanea O (2006) Hyperfunctioning intrathyroidal parathyroid carcinoma. Saudi Med J 27(8):447–450

    Google Scholar 

  8. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM Jr, Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R (2004) Parathyroid carcinoma: a 22-year experience. Head Neck 26(8):716–726

    Article  PubMed  Google Scholar 

  9. Beus KS, Stack BC Jr (2004) Parathyroid carcinoma. Otolaryngol Clin North Am 37:845–854

    Article  PubMed  Google Scholar 

  10. Shane E (2001) Clinical review 122: parathyroid carcinoma. J Clin Endocrinol Metab 86:485–493

    Article  PubMed  CAS  Google Scholar 

  11. Rawat N, Khetan N, Williams DW, Baxter JN (2005) Parathyroid carcinoma. British J Surg 92:1345–1353

    Article  CAS  Google Scholar 

  12. Cryns VL, Thor A, Xu H et al (1994) Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med 330:757–761

    Article  PubMed  CAS  Google Scholar 

  13. Wassif WS, Minoz CF, Friedman E, Wong S, Weber G, Nordenskjold M et al (1993) Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab 77:1485–1489

    Article  PubMed  CAS  Google Scholar 

  14. Lang B, Lo CY (2006) Parathyroid cancer. Surg Oncol Clin N Am 15(3):573–584

    Article  PubMed  Google Scholar 

  15. Giessler GA, Beech DJ (2001) Nonfunctional parathyroid carcinoma. J Natl Med Assoc 93:251–255

    PubMed  CAS  Google Scholar 

  16. Babar-Craig H, Quaglia A, Stearns M (2005) Parathyroid carcinoma: a report of two cases and a concise review and update of the literature. J Laryngol Otol 119(7):577–580

    Article  PubMed  Google Scholar 

  17. Schantz A, Castleman B (1973) Parathyroid carcinoma. A study of 70 cases. Cancer 31(3):600–605

    Article  PubMed  CAS  Google Scholar 

  18. Bondeson L, Sandelin K, Grimelius L (1993) Histological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol 17:820–829

    Article  PubMed  CAS  Google Scholar 

  19. Rodan GA (2002) Bisphosphonates and primary hyperparathyroidism. J Bone Miner Res 17(Suppl 2):150–153

    Google Scholar 

  20. Barman Balfour JA, Scott LJ (2005) Cinacalcet hydrochloride. Drugs 65(2):271–281

    Article  PubMed  Google Scholar 

  21. Montenegro FL, Tavares MR, Durazzo MD, Cernea CR, Cordeiro AC, Ferraz AR (2006) Clinical suspicion and parathyroid carcinoma management. Sao Paulo Med J 124(1):42–44

    Article  PubMed  Google Scholar 

  22. Thompson SD, Prichard AJN (2004) The management of parathyroid carcinoma. Curr Opin Otolaryngol Head Neck Surg 12:93–97

    Article  PubMed  Google Scholar 

  23. Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P (2000) Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest 23:255–257

    PubMed  CAS  Google Scholar 

  24. Moley JF, Lairmore TC, Doherty GM, Brunt LM, DeBenedetti MK (1999) Preservation of the recurrent laryngeal nerves in thyroid and parathyroid reoperations. Surgery 126(4):673–677

    Article  PubMed  CAS  Google Scholar 

  25. Kebebew E, Arici C, Duh QY, Clark OH (2001) Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg 136(8):878–885

    Article  PubMed  CAS  Google Scholar 

  26. Brunt L, Sicard GA (1999) Surgical Therapy of parathyroid tumors. In: Thawley S, Panje W (eds) Comprehensive management of head and neck tumors, Second edition edn. W.B. Saunders, Philadelphia, p 1795

    Google Scholar 

  27. Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO (1992) Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg 16(4):724–731

    Article  PubMed  CAS  Google Scholar 

  28. Brassier AR, Nussbaum SR (1988) Hungry Bone Syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery. Am J Med 84:654–660

    Article  Google Scholar 

  29. Iacobone M, Lumachi F, Favia G (2004) Up-to-date on parathyroid carcinoma: analysis of an experience of 19 cases. J Surg Oncol 88(4):223–228

    Article  PubMed  Google Scholar 

  30. Shaha AR, Ferlito A, Rinaldo A (2001) Distant metastases from thyroid and parathyroid cancer. ORL J Otorhinolaryngol Relat Spec 63(4):243–249

    Article  PubMed  CAS  Google Scholar 

  31. Hundhal S, Fleming I, Fregmen A, Menck H (1999) Two hundred eighty- six cases of parathyroid carcinoma treated in the US between 1985 and 1995. A national cancer data base report. Cancer 86:538–544

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Universidad Industrial de Santander, Bucaramanga, Colombia

    Álvaro Antonio Herrera-Hernández

  2. Department of Anesthesiology, Universidad Industrial de Santander, Bucaramanga, Colombia

    Paola Aranda-Valderrama

  3. Hematology and Oncology Division, Moores Cancer Center, UCSD, La Jolla, CA, USA

    Julio Alexander Díaz-Pérez

  4. University of Santander, Bucaramanga, Colombia

    Julio Alexander Díaz-Pérez

  5. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Loren Paola Herrera

  6. Blood and Marrow Transplantation Division, Moores Cancer Center, UCSD, 3855 Health Sciences Drive, #0960, La Jolla, CA, 92093-0960, USA

    Julio Alexander Díaz-Pérez

Authors
  1. Álvaro Antonio Herrera-Hernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paola Aranda-Valderrama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Julio Alexander Díaz-Pérez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Loren Paola Herrera
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Julio Alexander Díaz-Pérez.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Herrera-Hernández, Á.A., Aranda-Valderrama, P., Díaz-Pérez, J.A. et al. Intrathyroidal parathyroid carcinoma in a pediatric patient. Pediatr Surg Int 27, 1361–1365 (2011). https://doi.org/10.1007/s00383-011-2904-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00383-011-2904-6

Keywords

Search

Navigation