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Extensive tumor calcification in response to pre-operative reductive chemotherapy in pediatric esthesioneuroblastoma: a case report

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Abstract

Esthesioneuroblastomas are uncommon tumors in pediatric patients and are typically treated with multimodal therapy. Changes in gross tumor quality and character in response to adjuvant treatment have not been clearly reported. We report the case of a 15-year-old female with a diagnosis of Kadish stage C esthesioneuroblastoma who was treated with neoadjuvant chemotherapy and surgical resection. The patient’s tumor demonstrated cytoreduction after chemotherapy but also was found to have calcified. A combined trans-frontal sinus craniotomy with endoscopic endonasal resection was performed and resulted in negative margins and good clinical outcome.

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Correspondence to Carl H. Snyderman.

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Michael McDowell, none. Souvik Roy, none. Ezequiel Goldschmidt, none. Paul Gardner, consultant/ownership interest for SPIWay, LLC and consultant for Stryker. Elizabeth Tyler-Kabara, none. Carl Snyderman, consultant/ownership interest for SPIWay, LLC.

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McDowell, M.M., Roy, S., Goldschmidt, E. et al. Extensive tumor calcification in response to pre-operative reductive chemotherapy in pediatric esthesioneuroblastoma: a case report. Childs Nerv Syst 36, 2099–2102 (2020). https://doi.org/10.1007/s00381-020-04545-2

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