Skip to main content

Advertisement

Log in

De novo cerebral arteriovenous malformations: is epileptic seizure a potential trigger?

  • Original Paper
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Material and methods

The pathogenesis of cerebral arteriovenous malformations (cAVMs) is still not well understood. Generally, cAVMs are thought to be congenital lesions originating prenatally. We report a 7-year-old boy diagnosed with a de novo cAVM after 3 years of recurrent epileptic seizures.

Results

MR imaging at 4 years of age was normal. Follow-up MR imaging 3 years later demonstrated a de novo 2-cm cAVM in the right occipital lobe, confirmed by conventional angiography. We reviewed five previously reported cases of de novo cAVMs who did not have a previous neurovascular abnormality. Including our case, recurrent epileptic seizures are the major presentation (83.3 %) before de novo cAVM occurrence.

Conclusion

We suggest that epileptic seizure is a potential trigger of de novo cAVMs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Abdulrauf SI, Malik GM, Awad IA (1999) Spontaneous angiographic obliteration of cerebral arteriovenous malformations. Neurosurgery 44(280–287):287–288

    Google Scholar 

  2. Akimoto H, Komatsu K, Kubota Y (2003) Symptomatic de novo arteriovenous malformation appearing 17 years after the resection of two other arteriovenous malformations in childhood: case report. Neurosurgery 52(228–231):231–232

    Google Scholar 

  3. Alvarez H, Perry V, Solle M, Castillo M (2012) De novo cerebral arteriovenous malformation in a child with previous cavernous malformation and developmental venous anomaly. J Neurosurg Pediatr 9:327–330

    Article  PubMed  Google Scholar 

  4. Bai Y, He C, Zhang H, Ling F (2012) De novo multiple dural arteriovenous fistulas and arteriovenous malformation after embolization of cerebral arteriovenous fistula: case report. Childs Nerv Syst 28:1981–1983

    Article  PubMed  Google Scholar 

  5. Bendok BR, Getch CC, Ali MJ, Parish T, Batjer HH (2002) Spontaneous thrombosis of a residual arteriovenous malformation in eloquent cortex after surgery: case report. Neurosurgery 50(1142–1145):1145–1146

    Google Scholar 

  6. Bulsara KR, Alexander MJ, Villavicencio AT, Graffagnino C (2002) De novo cerebral arteriovenous malformation: case report. Neurosurgery 50(1137–1140):1140–1141

    Google Scholar 

  7. Choi JH, Mohr JP (2005) Brain arteriovenous malformations in adults. Lancet Neurol 4:299–308

    Article  PubMed  Google Scholar 

  8. Desal HA, Lee SK, Kim BS, Raoul S, Tymianski M, TerBrugge KG (2005) Multiple de novo vascular malformations in relation to diffuse venous occlusive disease: a case report. Neuroradiology 47:38–42

    Article  CAS  PubMed  Google Scholar 

  9. Fierstra J, Conklin J, Krings T, Slessarev M, Han JS, Fisher JA, Terbrugge K, Wallace MC, Tymianski M, Mikulis DJ (2011) Impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations. Brain 134:100–109

    Article  PubMed  Google Scholar 

  10. Friedman JA, Pollock BE, Nichols DA (2000) Development of a cerebral arteriovenous malformation documented in an adult by serial angiography. Case report. J Neurosurg 93:1058–1061

    Article  CAS  PubMed  Google Scholar 

  11. Gonzalez LF, Bristol RE, Porter RW, Spetzler RF (2005) De novo presentation of an arteriovenous malformation. Case report and review of the literature. J Neurosurg 102:726–729

    Article  PubMed  Google Scholar 

  12. Hashimoto T, Lawton MT, Wen G, Yang GY, Chaly TJ, Stewart CL, Dressman HK, Barbaro NM, Marchuk DA, Young WL (2004) Gene microarray analysis of human brain arteriovenous malformations. Neurosurgery 54(410–423):423–425

    Google Scholar 

  13. Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL (2011) Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl 111:83–92

    Article  PubMed Central  PubMed  Google Scholar 

  14. Mahajan A, Manchandia TC, Gould G, Bulsara KR (2010) De novo arteriovenous malformations: case report and review of the literature. Neurosurg Rev 33:115–119

    Article  PubMed  Google Scholar 

  15. Mast H, Koennecke HC, Meisel J, Osipov A, Hartmann A, Lasjaunias P, Pile-Spellman J, Hacein-Bey L, Young WL, Mohr JP (1998) Therapy of cerebral arteriovenous malformations. Nervenarzt 69:287–295

    Article  CAS  PubMed  Google Scholar 

  16. Mathon B, Blauwblomme T, Bolle S, Dufour C, Nagarra O, Brunelle F, Puget S (2013) De novo arteriovenous malformation after brain radiotherapy for medulloblastoma in a child. Neurology 81:398–399

    Article  PubMed  Google Scholar 

  17. Mendelow AD, Erfurth A, Grossart K, Macpherson P (1987) Do cerebral arteriovenous malformations increase in size? J Neurol Neurosurg Psychiatry 50:980–987

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Morioka T, Nishio S, Hikita T, Chung LH, Soejima T (1988) Marked growth of an angiographically occult arteriovenous malformation: case report. Neurosurgery 23:101–103

    Article  CAS  PubMed  Google Scholar 

  19. Mullan S, Mojtahedi S, Johnson DL, Macdonald RL (1996) Embryological basis of some aspects of cerebral vascular fistulas and malformations. J Neurosurg 85:1–8

    Article  CAS  PubMed  Google Scholar 

  20. Murphy PA, Lu G, Shiah S, Bollen AW, Wang RA (2009) Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. Lab Investig 89:971–982

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Nikitidou L, Kanter-Schlifke I, Dhondt J, Carmeliet P, Lambrechts D, Kokaia M (2012) VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures. PLoS One 7:e40535

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Nilsson I, Rolny C, Wu Y, Pytowski B, Hicklin D, Alitalo K, Claesson-Welsh L, Wennstrom S (2004) Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development. FASEB J 18:1507–1515

    Article  CAS  PubMed  Google Scholar 

  23. O’Shaughnessy BA, DiPatri AJ, Parkinson RJ, Batjer HH (2005) Development of a de novo cerebral arteriovenous malformation in a child with sickle cell disease and moyamoya arteriopathy. Case report. J Neurosurg 102:238–243

    Article  PubMed  Google Scholar 

  24. Ozsarac M, Aksay E, Kiyan S, Unek O, Gulec FF (2012) De novo cerebral arteriovenous malformation: Pink Floyd’s song “Brick in the Wall” as a warning sign. J Emerg Med 43:e17–e20

    Article  PubMed  Google Scholar 

  25. Schmit BP, Burrows PE, Kuban K, Goumnerova L, Scott RM (1996) Acquired cerebral arteriovenous malformation in a child with moyamoya disease. Case report. J Neurosurg 84:677–680

    Article  CAS  PubMed  Google Scholar 

  26. Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843–845

    Article  CAS  PubMed  Google Scholar 

  27. Stevens J, Leach JL, Abruzzo T, Jones BV (2009) De novo cerebral arteriovenous malformation: case report and literature review. AJNR Am J Neuroradiol 30:111–112

    Article  CAS  PubMed  Google Scholar 

  28. van Beijnum J, van der Worp HB, Buis DR, Al-Shahi SR, Kappelle LJ, Rinkel GJ, van der Sprenkel JW, Vandertop WP, Algra A, Klijn CJ (2011) Treatment of brain arteriovenous malformations: a systematic review and meta-analysis. JAMA 306:2011–2019

    Article  PubMed  Google Scholar 

  29. Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL (2011) Arteriovenous malformation in the adult mouse brain resembling the human disease. Ann Neurol 69:954–962

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by a “National science and technology Support Plan” (No.2011BAI08B08, Principle investigator: Professor Shuo Wang) grant from the Ministry of Health of China

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shuo Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wu, J., Li, Y., Cao, Y. et al. De novo cerebral arteriovenous malformations: is epileptic seizure a potential trigger?. Childs Nerv Syst 30, 1277–1281 (2014). https://doi.org/10.1007/s00381-014-2413-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-014-2413-8

Keywords

Navigation