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Suprasellar ganglioglioma presenting with diabetes insipidus in a young boy: a rare clinical presentation

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Abstract

Objective

Gangliogliomas are rare tumors composed of an admixture of glial and neuronal components. These usually occur in young patients, who present with therapy-resistant seizures. Clinical presentation of ganglioglioma with diabetes insipidus is extremely rare with only one case reported earlier in the available literature. Due to this rarity, ganglioglioma is not considered in the differential diagnosis in a patient with diabetes insipidus.

Case

A 7-year boy presented with polyuria, polydipsia, and progressive visual loss for 18 months. Investigations revealed diabetes insipidus. Radiographic studies of the brain showed a solid and cystic mass in the suprasellar region effacing the third ventricle. Intraoperatively, diffuse thickening of bilateral optic nerves and optic chiasma was noted and a diagnosis of optic glioma was considered. A biopsy of the mass was taken, which on histopathological examination showed features of ganglioglioma. The patient was referred for further radiotherapy but was lost to follow-up.

Conclusion

Diabetes insipidus as a presenting symptom of ganglioglioma is extremely rare. This benign tumor should be kept in mind in patients with central diabetes insipidus and a suprasellar mass lesion. This report describes the second such case in the literature.

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Authors and Affiliations

  1. Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Ruchika Gupta, Vaishali Suri, Raman Arora, Mehar C. Sharma & Chitra Sarkar

  2. Department of Neurosurgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

    Shashwat Mishra & Manmohan Singh

Authors
  1. Ruchika Gupta
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  2. Vaishali Suri
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  3. Raman Arora
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  4. Mehar C. Sharma
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  5. Shashwat Mishra
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  6. Manmohan Singh
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  7. Chitra Sarkar
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Correspondence to Vaishali Suri.

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Gupta, R., Suri, V., Arora, R. et al. Suprasellar ganglioglioma presenting with diabetes insipidus in a young boy: a rare clinical presentation. Childs Nerv Syst 26, 255–258 (2010). https://doi.org/10.1007/s00381-009-0989-1

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  • DOI: https://doi.org/10.1007/s00381-009-0989-1

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