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The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit

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Abstract

Ongoing myocardial damage at the acme of the sepsis status has not been sufficiently evaluated. The clinical data of 160 sepsis patients who require intensive care and 127 outpatients with chronic heart failure (HF) were compared as a retrospective cohort study. Thereafter, the sepsis patients were divided into 3 groups according to the serum heart-type fatty acid-binding protein (H-FABP) quartiles [low H-FABP = Q1 (n = 39), middle H-FABP = Q2/Q3 (n = 81), and high H-FABP = Q4 group (n = 40)]. The H-FABP level was measured within 15 min of admission. The serum H-FABP levels in the sepsis patients [26.6 (9.3–79.0) ng/ml] were significantly higher than in the choric HF patients [6.6 (4.6–9.7) ng/ml]. A Kaplan–Meier curve showed that the survival rate of the high-H-FABP group was significantly lower than that of the middle- and low-H-FABP groups. The multivariate Cox regression analysis for the 365-day mortality showed that the high-H-FABP group (hazard ratio: 6.544, 95% confidence interval [CI] 2.026–21.140; p = 0.002) was an independent predictor of the 365-day mortality. The same trend in the prognostic impact was significantly (p = 0.015) observed in the cohort that had not been suffering from the cardiac disease before admission. The serum H-FABP level was an independent predictor of the 365-day mortality in the patients who were emergently hospitalized in the intensive-care unit due to sepsis. Ongoing myocardial damage was detected in the majority of patients with sepsis, suggesting that ongoing myocardial damage might be a candidate predictor of adverse outcomes in sepsis patients.

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Acknowledgements

We are grateful to the staff of the ICU and medical records office at Chiba Hokusoh Hospital, Nippon Medical School for collecting the medical data.

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None declared.

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Authors and Affiliations

  1. Division of Intensive Care Unit, Nippon Medical School, Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba, 270-1694, Japan

    Kenichi Tani, Akihiro Shirakabe, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Shota Shigihara, Tomofumi Sawatani, Yusuke Otsuka, Noritake Hata & Kuniya Asai

  2. Department of Internal Medicine, Toho Kamagaya Hospital, Chiba, Japan

    Tsutomu Takayasu

  3. Department of Internal Medicine, Hasegawa Hospital, Chiba, Japan

    Miwako Asano

  4. Department of Internal Medicine, Kanamachi Daiichi Hospital, Tokyo, Japan

    Akiko Nomura

  5. Department of Cardiovascular Medicine, Nippon Medical School Hospital, Tokyo, Japan

    Wataru Shimizu

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  1. Kenichi Tani
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Correspondence to Akihiro Shirakabe.

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Tani, K., Shirakabe, A., Kobayashi, N. et al. The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit. Heart Vessels 36, 1765–1774 (2021). https://doi.org/10.1007/s00380-021-01865-4

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