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Pulmonary annular motion velocity reflects right ventricular outflow tract function in children with surgically repaired congenital heart disease

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Abstract

Right ventricular (RV) dysfunction is generally evaluated using analyses of tricuspid annular motion. However, it represents only one aspect of RV performance. Whether measuring pulmonary annular motion velocity could serve as a novel way to evaluate global RV and/or RV outflow tract (RVOT) performance in pediatric congenital heart disease (CHD) patients with surgically repaired RVOT was evaluated. In this prospective study, tissue Doppler-derived pulmonary annular motion velocity was measured in children (aged 2–5 years) with RVOT reconstruction (RVOTR group, n = 48) and age-matched healthy children (Control, n = 60). The types of RVOTR procedures were as follows: pulmonary valve-sparing procedure (PVS, n = 7); transannular patch with monocusp valve reconstruction (TAP, n = 29); and RV-to-PA conduit reconstruction using a pericardial valve with expanded polytetrafluoroethylene conduit (Rastelli, n = 12). Pulmonary annular motion velocity waveforms comprised systolic bimodal (s1′ and s2′) and diastolic e′ and a′ waves in all participants. The peak velocities of s1′, s2′, e′, and a′ were significantly lower in the RVOTR group than in the control group (all p < 0.0001). Furthermore, these parameters depended significantly on the type of surgical procedure. The peak velocities of s1′, s2′, and e′ had significant correlations with RVOT ejection fraction (RVOT-EF) (r = 0.56, 0.49, and 0.34, respectively), and RVOT fractional shortening (RVOT-FS) (r = 0.72, 0.55, and 0.41, respectively), although there were no significant correlations between pulmonary annular motion and global RV function, including RV ejection fraction (RVEF) and RV fractional area change (RVFAC) in the assessment of all RVOTR group patients. The pulmonary annular motion parameters in the PVS group had significant correlations with both global RV and RVOT performance. The TAP group showed significant correlations between RVOT function and pulmonary annular motion. The Rastelli group showed almost no significant correlations between RV/RVOT function and tissue Doppler parameters. Pulmonary annular motion velocity is a simple, rapid, reproducible, and useful method of assessing RVOT function in children with surgically repaired CHD.

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Authors and Affiliations

  1. Department of Pediatrics, Tokushima University, Kuramoto-cho 3, Tokushima, 770-8305, Japan

    Yasunobu Hayabuchi, Akemi Ono, Yukako Homma & Shoji Kagami

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  1. Yasunobu Hayabuchi
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  2. Akemi Ono
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  3. Yukako Homma
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  4. Shoji Kagami
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Correspondence to Yasunobu Hayabuchi.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants’ parents included in the study.

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Hayabuchi, Y., Ono, A., Homma, Y. et al. Pulmonary annular motion velocity reflects right ventricular outflow tract function in children with surgically repaired congenital heart disease. Heart Vessels 33, 316–326 (2018). https://doi.org/10.1007/s00380-017-1061-9

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  • DOI: https://doi.org/10.1007/s00380-017-1061-9

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