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Hemodynamic response during standing test after blood donation can predict the late phase vasovagal reaction

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Abstract

A major complication of blood donation is vasovagal reaction (VVR) with or without syncope. VVR occurs not only in the early phase, but also in the late phase after blood donation. We previously reported the hemodynamic characteristics of blood donors susceptible to early phase VVR. In the present study, we investigated the hemodynamic characteristics of those who developed late VVR. Ninety-six healthy volunteers donating 400 ml of whole blood were studied. After asking about their physical condition or routine questions for blood donation, blood pressure (BP) and heart rate (HR) were recorded while the donors were kept standing up for 3 min before and after blood collection. Questionnaires were distributed to all donors for reporting late VVR symptoms within 24 h. Those with younger age and lower diastolic blood pressure were more susceptible to late VVR (both p < 0.05). Furthermore, we identified the increase in HR during the standing test after blood collection as a good predictor of late VVR (odds ratio 1.063, 95 % CI 1.005–1.124; p = 0.031). Also, analysis of questions asked before donation revealed that significantly more donors considered themselves as sensitive to pain in the late VVR group (Odds ratio 0.070, 95 % CI 0.008–0.586; p = 0.014). Excessive HR response to standing after blood collection and subjective sensitivity to pain as well as younger age and lower diastolic BP may be useful to detect donors at high risk for late VVR.

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Acknowledgments

We sincerely appreciate Kazuko Murakami and the technical assistance of all the staff, especially of the Fukuoka Red Cross blood collection center and the statistical advice of Mr. Yonemoto.

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Authors and Affiliations

  1. Fukuokaken Saiseikai Futsukaichi Hospital, Fukuoka, Japan

    Masayoshi Yoshida, Emi Eura, Atsumi Hayashi, Natsumi Kawamura, Sumito Narita, Mari Matsumoto, Hidetoshi Momii & Toshiaki Kadokami

  2. Sleep Apnea Center, Kyushu University Hospital, 3-1-1 Maidashi, Higashiku, Fukuoka, 812-8582, Japan

    Shin-ichi Ando

  3. Fukuoka Blood Center, Fukuoka, Japan

    Hiroyuki Kiyokawa

Authors
  1. Masayoshi Yoshida
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  2. Shin-ichi Ando
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  3. Emi Eura
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  4. Atsumi Hayashi
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  5. Natsumi Kawamura
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  6. Sumito Narita
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  7. Mari Matsumoto
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  8. Hidetoshi Momii
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  9. Toshiaki Kadokami
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  10. Hiroyuki Kiyokawa
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Corresponding author

Correspondence to Shin-ichi Ando.

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There was no financial support, conflict of interest and off-label or investigational drug use.

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The patient has given informed consent for publication of the clinical data. The a of the patient has been protected.

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Yoshida, M., Ando, Si., Eura, E. et al. Hemodynamic response during standing test after blood donation can predict the late phase vasovagal reaction. Heart Vessels 31, 1997–2003 (2016). https://doi.org/10.1007/s00380-016-0829-7

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  • DOI: https://doi.org/10.1007/s00380-016-0829-7

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