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Relation of omega-3 fatty acid and C-reactive protein to peripheral artery disease in patients with coronary artery disease

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Abstract

Eicosapentaenoic acid (EPA), a member of the omega-3 polyunsaturated fatty acid family, prevents cardiovascular disease. C-reactive protein (CRP) is a marker of inflammation, which promotes atherosclerosis. The aim of this study was to investigate the relationship among EPA, CRP, and the prevalence of peripheral artery disease (PAD), which is a manifestation of systemic atherosclerosis. A cross-sectional study was performed on 238 patients with coronary artery disease (CAD). Blood EPA and CRP levels and ankle-brachial pressure indices were measured. Cut-off values for plasma EPA levels and serum CRP levels were determined using receiver operating characteristic (ROC) analysis. Patients with ABIs ≤0.9 were defined as having PAD. EPA levels were significantly lower and CRP levels were significantly higher in patients with PAD than in those without [48 (26–77) vs. 58 (41–83) μg/ml, p = 0.026 and 3.3 (0.64–14.0) vs. 0.70 (0.32, 2.4) mg/l, p = 0.004]. Multivariate analysis for PAD revealed that high CRP levels and low EPA levels were significant and independent predictors of PAD [odds ratio 3.1 (95 % CI 1.4–6.9), p = 0.006 and odds ratio 4.9 (95 % CI 1.5–9.7), p = 0.004]. Furthermore, to predict PAD, adding high CRP levels and low EPA levels to the established risk factors significantly improved the area under the ROC curves, from 0.66 to 0.78, of the PAD prediction model (p = 0.004). A significant relationship among EPA, CRP, and PAD was confirmed in patients with CAD.

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Authors and Affiliations

  1. Department of Cardiology, Ichinomiya Municipal Hospital, Ichinomiya, Japan

    Tsuyoshi Sugiura

  2. Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Daiji Yoshikawa, Hideki Ishii, Susumu Suzuki, Soichiro Kumagai, Yosuke Inoue, Satoshi Okumura, Satoshi Isobe, Mutsuharu Hayashi & Toyoaki Murohara

  3. Department of Cardiology, Aichi Medical University, Nagakute, Japan

    Hirohiko Ando & Tetsuya Amano

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  1. Tsuyoshi Sugiura
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  2. Daiji Yoshikawa
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Correspondence to Daiji Yoshikawa.

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Sugiura, T., Yoshikawa, D., Ishii, H. et al. Relation of omega-3 fatty acid and C-reactive protein to peripheral artery disease in patients with coronary artery disease. Heart Vessels 29, 449–455 (2014). https://doi.org/10.1007/s00380-013-0384-4

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  • DOI: https://doi.org/10.1007/s00380-013-0384-4

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