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Patient mit membranoproliferativer Glomerulonephritis Typ II

Intravitreale Bevacizumab-Therapie der choroidalen Neovaskularisation

Patient with type II membranoproliferative glomerulonephritis

Intravitreal bevacizumab therapy for choroidal neovascularization

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Zusammenfassung

Die membranoproliferative Glomerulonephritis (MPGN) Typ II ist eine seltene systemische Erkrankung, die durch elektronenmikroskopisch anfärbbare, dichte Ablagerungen („dense deposits“) in der glomerulären Basalmembran und auch in der Bruch-Membran der Netzhaut charakterisiert ist. Obwohl die Mehrheit der Patienten asymptomatische Drusen aufweist, kann der Visus durch die Entwicklung einer choroidalen Neovaskularisation stark beeinträchtigt werden. Wir präsentieren einen Patienten mit MPGN Typ II, der eine choroidale Neovaskularisation entwickelte, die mit einer einzigen intravitrealen Bevacizumab-Injektion erfolgreich behandelt wurde. Sechs Monate nach Behandlung war der Patient weiterhin beschwerdefrei.

Abstract

Membranoproliferative glomerulonephritis (MPGN) type II is a rare disease characterized by electron dense deposits on the basement membrane in the glomeruli of the kidneys and also in Bruch’s membrane of the eye. Although most patients have asymptomatic drusen of the retina choroidal neovascularization can sometimes develop, which can permanently affect visual acuity. We report an unusual case of choroidal neovascularization in a patient with MPGN type II that was successfully treated with a single intravitreal injection of bevacizumab. The 6 months follow-up showed no recurrence of choroidal neovascularization.

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Authors and Affiliations

  1. Moorfields Eye Hospital, 162 City Road, EC1V 2PD, London, UK

    M. Karampelas, N. Kopsachilis MD, J.H. Chang & B. Pal

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  1. M. Karampelas
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  2. N. Kopsachilis MD
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  3. J.H. Chang
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  4. B. Pal
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Correspondence to N. Kopsachilis MD.

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Karampelas, M., Kopsachilis, N., Chang, J. et al. Patient mit membranoproliferativer Glomerulonephritis Typ II. Ophthalmologe 109, 791–793 (2012). https://doi.org/10.1007/s00347-012-2550-y

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  • DOI: https://doi.org/10.1007/s00347-012-2550-y

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