Skip to main content
SpringerLink
Log in

AR-V7 predicting treatment response in metastasized prostate cancer: has it peaked?

  • Letter to the Editor
  • Published:
World Journal of Urology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Abbreviations

mCRPC:

Metastasized castration-resistant prostate cancer

AR-V7:

Androgen receptor splice variant 7

CTCs:

Circulating tumor cells

ARSIs:

Androgen receptor signaling inhibitors

OS:

Overall survival

HR:

Hazard ratio

References

  1. Taplin M-E, Antonarakis ES, Ferrante KJ, Horgan K, Blumenstein BA, Saad F, Luo J, De Bono JS (2017) Clinical factors associated with AR-V7 detection in ARMOR3-SV, a randomized trial of galeterone (Gal) vs enzalutamide (Enz) in men with AR-V7 + metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol 35:(suppl; abstr 5005)

  2. Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, Chen Y, Mohammad TA, Chen Y, Fedor HL, Lotan TL, Zheng Q, De Marzo AM, Isaacs JT, Isaacs WB, Nadal R, Paller CJ, Denmeade SR, Carducci MA, Eisenberger MA, Luo J (2014) AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med 371:1028–1038

    Article  PubMed  PubMed Central  Google Scholar 

  3. Antonarakis ES, Lu C, Luber B, Wang H, Chen Y, Nakazawa M, Nadal R, Paller CJ, Denmeade SR, Carducci MA, Eisenberger MA, Luo J (2015) Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer. JAMA Oncol 1:582–591

    Article  PubMed  PubMed Central  Google Scholar 

  4. Bernemann C, Schnoeller TJ, Luedeke M, Steinestel K, Boegemann M, Schrader AJ, Steinestel J (2017) Expression of AR-V7 in circulating tumour cells does not preclude response to next generation androgen deprivation therapy in patients with castration resistant prostate cancer. Eur Urol 71:1–3

    Article  CAS  PubMed  Google Scholar 

  5. Qu F, Xie W, Nakabayashi M, Zhang H, Jeong SH, Wang X, Komura K, Sweeney CJ, Sartor O, Lee GM, Kantoff PW (2017) Association of AR-V7 and prostate-specific antigen rna levels in blood with efficacy of abiraterone acetate and enzalutamide treatment in men with prostate cancer. Clin Cancer Res 23:726–734

    Article  CAS  PubMed  Google Scholar 

  6. Scher HI, Graf RP, Schreiber NA, McLaughlin B, Lu D, Louw J, Danila DC, Dugan L, Johnson A, Heller G, Fleisher M, Dittamore R (2017) Nuclear-specific AR-V7 protein localization is necessary to guide treatment selection in metastatic castration-resistant prostate cancer. Eur Urol 71:874–882

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We are thankful to Mrs. Rita Duchin, RDESIGN, email: office@rdesign.co.il, for her assistance in designing the diagram.

Author information

Authors and Affiliations

  1. Department of Urology and Pediatric Urology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany

    Igor Tsaur & Hendrik Borgmann

  2. Centre of Urological Surgery, Dialysis and Renal Transplantation, Fundeni Clinical Institute, Bucharest, Romania

    Christian I. Surcel

  3. Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium

    Piet Ost

  4. Institut universitaire du cancer Toulouse-Oncopole, Toulouse, France

    Guillaume Ploussard

  5. Service d’urologie, Saint Jean Languedoc Hospital, Toulouse, France

    Guillaume Ploussard

Authors
  1. Igor Tsaur
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hendrik Borgmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christian I. Surcel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Piet Ost
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Guillaume Ploussard
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

IT: project development, manuscript writing. HB: manuscript writing. CIS: manuscript writing. PO: manuscript writing. GP: project development, manuscript writing

Corresponding author

Correspondence to Igor Tsaur.

Ethics declarations

Conflict of interest

The authors declare that there are no conflicts of interest.

Research involving human participants

For this type of study formal consent is not required.

Informed consent

For this type of study informed consent is not required.

Additional information

All authors are the members of Prostate Cancer Working Group of Young Academic Urologists Working Party of European Association of Urology.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tsaur, I., Borgmann, H., Surcel, C.I. et al. AR-V7 predicting treatment response in metastasized prostate cancer: has it peaked?. World J Urol 36, 149–151 (2018). https://doi.org/10.1007/s00345-017-2107-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00345-017-2107-4

Search

Navigation