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Do pure squamous cell carcinomas and urothelial carcinomas have similar prognosis after radical cystectomy?

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Abstract

Purpose

The purpose of this study was to evaluate the surgical treatment results of urothelial carcinoma (UC) and pure squamous cell carcinoma of the bladder (SCC).

Methods

The records of 460 patients who have undergone radical cystectomy in our department between the years 1991 and 2011 were analyzed retrospectively, and 364 patients with UC and 60 patients with pure SCC were evaluated.

Results

Average ages of the patients with UC and SCC were 61.12 ± 8.9 and 59.38 ± 8.6 years, respectively (p = 0.902). UC group had 29 female patients, whereas SCC group had 9 female patients (p = 0.077). The mean follow-up periods were 26.09 ± 24.75 months for UC group and 22.23 ± 31.01 months for SCC group (p = 0.805). The incidence of organ-confined, extravesical, lymph node-positive diseases in UC and SCC cases was 48.9 and 32.2, 29.3 and 32.2 %, 21.8 and 35.6 %, respectively (p = 0.028). Five-year disease-specific survival (DSS) rates were 57.5 % in UC and 39.1 % in SCC group (p = 0.011). Five-year DSS rates were 81.2 % in UC and 75.0 % in SCC group in organ-confined disease (p = 0.534) and 28.2 % in UC and 40.9 % in SCC group in extravesical disease (p = 0.845). In lymph node-positive patients, DSS time was 20.9 ± 2.85 months in UC and 12.8 ± 2.07 months in SCC patients (p = 0.182). In multivariate analysis, pT stage (HR: 2.221; 95 % CI: 1.695–2.911) and lymph node involvement (HR: 2.863; 95 % CI: 1.819–4.509) were independently associated with DSS (p < 0.001), but histological subtype (HR: 1.423; 95 % CI: 0.798–2.538) was not a statistically significant factor (p = 0.232).

Conclusions

Although pure SCC cases are diagnosed at advanced stages of the disease, UC and pure SCC cases have similar prognosis by stages. Lymph node involvement and stages are the most important prognostic factors after radical cystectomy.

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References

  1. Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60(5):277–300

    Article  PubMed  Google Scholar 

  2. Rogers CG, Palapattu GS, Shariat SF et al (2006) Clinical outcomes following radical cystectomy for primary nontransitional cell carcinoma of the bladder compared to transitional cell carcinoma of the bladder. J Urol 175(6):2048–2053

    Article  PubMed  Google Scholar 

  3. Ploeg M, Aben KK, Kiemeney LA (2009) The present and future burden of urinary bladder cancer in the world. World J Urol 27:289–293

    Article  PubMed  Google Scholar 

  4. Stein JP, Lieskovsky G, Cote R et al (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19:666–675

    PubMed  CAS  Google Scholar 

  5. Rundle JS, Hart AJ, McGeorge A, Smith JS, Malcolm AJ, Smith PM (1982) Squamous cell carcinoma of bladder. A review of 114 patients. Br J Urol 54(5):522–526

    Article  PubMed  CAS  Google Scholar 

  6. Porter MP, Voigt LF, Penson DF, Weiss NS (2002) Racial variation in the incidence of squamous cell carcinoma of the bladder in the United States. J Urol 168(5):1960–1963

    Article  PubMed  Google Scholar 

  7. Ghoneim MA, el-Mekresh M, el-Baz MA, el-Attar IA, Ashamallah A (1997) Radical cystectomy for carcinoma of the bladder: critical evaluation of the results in 1026 cases. J Urol 158:393–399

    Article  PubMed  CAS  Google Scholar 

  8. Kantor AF, Hartge P, Hoover RN, Fraumeni JF Jr (1988) Epidemiological characteristics of squamous cell carcinoma and adenocarcinoma of the bladder. Cancer Res 1;48(13):3853–3855

    Google Scholar 

  9. Scosyrev E, Yao J, Messing E (2009) Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? Urology 73(4):822–827

    Article  PubMed  Google Scholar 

  10. Bassi P, Ferrante GD, Piazza N et al (1999) Prognostic factors of outcome after radical cystectomy for bladder cancer: a retrospective study of a homogeneous patient cohort. J Urol 161(5):1494–1497

    Article  PubMed  CAS  Google Scholar 

  11. Hong SK, Kwak C, Jeon HG, Lee E, Lee SE (2005) Do vascular, lymphatic, and perineural invasion have prognostic implications for bladder cancer after radical cystectomy? Urology 65(4):697–702

    Article  PubMed  Google Scholar 

  12. Stein JP, Cai J, Groshen S, Skinner DG (2003) Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density. J Urol 170(1):35–41

    Article  PubMed  Google Scholar 

  13. Nishiyama H, Habuchi T, Watanabe J et al (2004) Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990–2000 in Japan. Eur Urol 45(2):176–181

    Article  PubMed  Google Scholar 

  14. Girgin C, Sezer A, Uc R, Ermete M, Ozkan U, Gurel G (2003) Outcome of the treatment of invasive non-transitional cell carcinoma. Int J Urol 10(10):525–529

    Article  PubMed  Google Scholar 

  15. Richie JP, Waisman J, Skinner DG, Dretler SP (1976) Squamous carcinoma of the bladder: treatment by radical cystectomy. J Urol 115(6):670–672

    PubMed  CAS  Google Scholar 

  16. Shokeir AA (2004) Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment. BJU Int 93(2):216–220

    Article  PubMed  CAS  Google Scholar 

  17. Kastritis E, Dimopoulos MA, Antoniou N et al (2006) The outcome of patients with advanced pure squamous or mixed squamous and transitional urothelial carcinomas following platinum-based chemotherapy. Anticancer Res 26(5B):3865–3869

    Google Scholar 

  18. Abdollah F, Sun M, Jeldres C et al (2011) Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma: a competing-risks analysis. BJU Int. doi:10.1111/j.1464-410X.2011.10357.x

    Google Scholar 

  19. Stein JP, Lieskovsky G, Cote R et al (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19(3):666–675

    PubMed  CAS  Google Scholar 

  20. Wallmeroth A, Wagner U, Moch H, Gasser TC, Sauter G, Mihatsch MJ (1999) Patterns of metastasis in muscle-invasive bladder cancer (pT2-4): an autopsy study on 367 patients. Urol Int 62(2):69–75

    Article  PubMed  CAS  Google Scholar 

  21. Stein JP, Skinner DG (2005) The role of lymphadenectomy in high-grade invasive bladder cancer. Urol Clin N A 32(2):187–197

    Article  PubMed  Google Scholar 

  22. Herr HW (2003) Extent of surgery and pathology evaluation has an impact on bladder cancer outcomes after radical cystectomy. Urology 61(1):105–108

    Article  PubMed  Google Scholar 

  23. May M, Herrmann E, Bolenz C et al (2011) Association between the number of dissected lymph nodes during pelvic lymphadenectomy and cancer-specific survival in patients with lymph node-negative urothelial carcinoma of the bladder undergoing radical cystectomy. Ann Surg Oncol 18(7):2018–2025

    Article  PubMed  Google Scholar 

  24. Stein JP, Cai J, Groshen S, Skinner DG (2003) Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density. J Urol 170(1):35–41

    Article  PubMed  Google Scholar 

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Ataturk Training and Research Hospital, Urology Clinic Basın Sitesi, 35360, Izmir, Turkey

    Ugur Balci, Kutan Ozer, Sacit Nuri Gorgel, Ertugrul Sefik & Cengiz Girgin

  2. Department of Urology, Katip Celebi University Medicine School, Izmir, Turkey

    Cetin Dincel

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  1. Ugur Balci
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  2. Kutan Ozer
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  3. Sacit Nuri Gorgel
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  4. Ertugrul Sefik
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  5. Cengiz Girgin
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  6. Cetin Dincel
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Correspondence to Ugur Balci.

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Balci, U., Ozer, K., Gorgel, S.N. et al. Do pure squamous cell carcinomas and urothelial carcinomas have similar prognosis after radical cystectomy?. World J Urol 31, 1177–1182 (2013). https://doi.org/10.1007/s00345-012-0872-7

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  • DOI: https://doi.org/10.1007/s00345-012-0872-7

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