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QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells

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Abstract

The development of a sensitive sensor for detecting nitric oxide (NO) emissions from biological samples is reported. The sensor is based on tunable diode laser absorption spectroscopy (TDLAS) using a continuous wave, thermoelectrically cooled quantum cascade laser (QCL) and a 100-m astigmatic Herriot cell. A 2f-wavelength modulation spectroscopy technique was used to obtain QCL-based TDLAS NO emission measurements with an optimum signal-to-noise ratio. An absorption line at 1,900.076 cm−1 was targeted to measure NO with a minimum detection limit of 124 ppt. Positive control measurements with the NO donor DETA NONOate were performed to determine and optimize the sensor performance for measurements of biological samples. Our measurements with NO donor show the potential suitability of the sensor for monitoring NO emission from cancer cells for biological investigations.

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Acknowledgments

The authors acknowledge Dr. C. Bauer from Testo AG, Germany, for providing the CW TEC DFB QCL.

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Authors and Affiliations

  1. Rice University, 6100 Main St., Houston, TX, 77005, USA

    M. Köhring, S. Huang, M. Jahjah, W. Jiang, W. Ren, C. Caneba, L. Yang, D. Nagrath & F. K. Tittel

  2. Fraunhofer Heinrich-Hertz-Institute, Am Stollen 19B, 38640, Goslar, Germany

    M. Köhring & W. Schade

  3. Princeton University, Princeton, NJ, 08540, USA

    S. Huang

  4. EFZN, Clausthal University of Technology, Am Stollen 19B, 38640, Goslar, Germany

    U. Willer

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  1. M. Köhring
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  2. S. Huang
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  3. M. Jahjah
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  4. W. Jiang
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  7. C. Caneba
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  8. L. Yang
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Correspondence to M. Köhring or F. K. Tittel.

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Köhring, M., Huang, S., Jahjah, M. et al. QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells. Appl. Phys. B 117, 445–451 (2014). https://doi.org/10.1007/s00340-014-5853-7

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  • DOI: https://doi.org/10.1007/s00340-014-5853-7

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