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Feasibility of 320-row area detector CT coronary angiography using 40 mL of contrast material: assessment of image quality and diagnostic accuracy

  • Cardiac
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Abstract

Objectives

To assess the image quality and diagnostic accuracy of 320-row area detector CT (320-ADCT) coronary angiography using 40 mL of contrast material in comparison with 60-mL protocol.

Methods

This retrospective study included 183 patients who underwent 320-ADCT coronary angiography using 40 mL of contrast and additional 183 sex- and body mass index-matched patients using 60 mL of contrast constituting the control group. Both groups used the same 5-mL/sec injection rate. Quantitative image quality measurements and diagnostic accuracies were calculated and compared.

Results

Mean attenuation and contrast-to-noise ratio (CNR) at the aorta and all coronary arteries were lower in the 40-mL group than in the 60-mL group (all, p < 0.05), except for the CNR at proximal coronary arteries at 100 kVp (p = 0.073). However, the proportion of coronary segments with vessel attenuation >250 HU was not different between groups (all, p > 0.05), except for distal coronary arteries at 80 kVp (p = 0.001). Furthermore, there were no differences in per-patient and per-segment diagnostic accuracies between the groups (all, p > 0.05).

Conclusions

320-ADCT coronary angiography using 40 mL of contrast showed image quality and diagnostic accuracy comparable to the 60-mL protocol, demonstrating the clinical feasibility of lowering the risk of contrast-induced nephropathy through contrast volume reduction.

Key points

• 320-ADCT might enable reduction of contrast material volume.

• A 40-mL contrast protocol for 320-ADCT provided acceptable image quality.

• A 40-mL contrast protocol for 320-ADCT demonstrated sufficient diagnostic accuracy.

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Abbreviations

320-ADCT:

320-row area detector computed tomography

BMI:

Body mass index

CIN:

Contrast-induced nephropathy

CNR:

contrast-to-noise ratio

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Acknowledgments

We would like to acknowledge Ms. Hyunsook Hong from the medical research collaborating center of our institution for her assistance with the statistical analysis. The scientific guarantor of this publication is Jin Wook Chung.

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. Institutional review board approval was obtained. Written informed consent was waived by the institutional review board. Methodology: retrospective, case-control study, performed at one institution.

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Authors and Affiliations

  1. Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Rihyeon Kim, Eun-Ah Park, Whal Lee & Jin Wook Chung

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  1. Rihyeon Kim
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  2. Eun-Ah Park
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  3. Whal Lee
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Correspondence to Eun-Ah Park.

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Kim, R., Park, EA., Lee, W. et al. Feasibility of 320-row area detector CT coronary angiography using 40 mL of contrast material: assessment of image quality and diagnostic accuracy. Eur Radiol 26, 3802–3810 (2016). https://doi.org/10.1007/s00330-016-4275-9

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  • DOI: https://doi.org/10.1007/s00330-016-4275-9

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