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Diagnostic performance of CT and MRI in distinguishing intraductal papillary neoplasm of the bile duct from cholangiocarcinoma with intraductal papillary growth

  • Hepatobiliary-Pancreas
  • Published:
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Abstract

Objectives

We aimed to evaluate the diagnostic performance of CT and MRI for distinguishing intraductal papillary neoplasm of the bile duct (IPNB) from cholangiocarcinoma (CC) with intraductal papillary growth (IPG).

Methods

Forty-two patients with either IPNB or CC with IPG proven by histopathology were independently reviewed in retrospect. Strict criteria for diagnosis of IPNB included presence of the designated imaging features as follows: local dilatation of the bile duct, nodule within the dilated bile duct, growing along the interior wall of bile duct. Any lesion that was not consistent with the criteria was classified as CC with IPG. Sensitivity, specificity, positive and negative predictive values for characterization of IPNB were calculated, and k test was used to assess the level of agreement.

Results

Two imaging reviewers correctly identified 21 of 26 (80.8 %) and 22 of 26 (84.6 %) IPNB cases, respectively. Alternatively, they correctly identified 14 of 16 (87.5 %) and 15 of 16 (93.8 %) CC with IPG, respectively. Agreement between the two reviewers was perfect (k = 0.81) for the diagnosis of IPNB and differentiation from CC with IPG.

Conclusions

By using our designated diagnostic criteria of CT and MRI, IPNB can be accurately identified and possible to be distinguished from CC with IPG.

Key points

IPNB can accurately be identified by using defined diagnostic criteria at CT/MRI.

IPNB has some characteristic CT and MR imaging features.

IPNB is a rare entity; up until now it might have been misdiagnosed.

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Abbreviations

IPNB:

Intraductal papillary neoplasm of the bile duct

CC:

Cholangiocarcinoma

IPG:

Intraductal papillary growth

IPN:

Intracystic papillary neoplasm

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Acknowledgments

The scientific guarantor of this publication is Changhong Liang. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. One of the authors has significant statistical expertise. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, cross sectional study / diagnostic or prognostic study / observational, performed at one institution.

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Correspondence to Changhong Liang.

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Liu, Y., Zhong, X., Yan, L. et al. Diagnostic performance of CT and MRI in distinguishing intraductal papillary neoplasm of the bile duct from cholangiocarcinoma with intraductal papillary growth. Eur Radiol 25, 1967–1974 (2015). https://doi.org/10.1007/s00330-015-3618-2

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  • DOI: https://doi.org/10.1007/s00330-015-3618-2

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