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Spectral CT imaging of myocardial infarction: preliminary animal experience

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Abstract

Objectives

To evaluate the capability of spectral CT imaging to detect the different stages and angiogenesis of myocardial infarction (MI).

Methods

MI was surgically induced in 40 rabbits that were evenly divided into four stages of MI: 6 h (6H), 3 days (3D), 7 days (7D) and 14 days (14D). Spectral CT was performed at 10 s, 1 min and 3 min after intravenous contrast medium administration. CD31 immunohistochemistry was used for the microvessel density (MVD) measurement. Iodine concentrations in the myocardium were measured and normalised to the aorta as nIC. The relationships between infarcted myocardial nIC and MVD were analysed.

Results

The nIC of infarct myocardium decreased at 10 s and increased in late-phase CT images. There were significant differences between the 6H and other groups (P 6H–3D   = 0.01, P 6H–7D   = 0.01, P 6H–14D   = 0.00). There was a significant difference in the MVD of infarct myocardium between the two groups except in the 7D and 14D groups (P = 0.08). In the 10-s phase, the nIC of infarct myocardium was negatively correlated with MVD (r = -0.54, P = 0.00), whereas in the late phases, there was a positive correlation between them (r = 0.57, P = 0.00 in the 1-min phase, r = 0.48, P = 0.00 in the 3-min phase).

Conclusion

Spectral CT imaging of the myocardium can be used to evaluate the different stages and angiogenesis of MI.

Key Points

• Multidetector CT is increasingly used to evaluate the heart.

• Spectral CT offers increased opportunities to assess the myocardium.

• In animals, spectral CT can evaluate different stages of myocardial infarction.

• Spectral CT findings correlated with the angiogenesis of myocardial infarction.

• Spectral CT can reflect dynamic changes of MI at low radiation doses.

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Acknowledgments

The authors wish to thank Dr. Li Jianying for his technical support in understanding the dual energy spectral CT imaging mode and in editing the manuscript. We specially thank Hai-peng Dong, Zhen-fang Wu, Wei-ping Shi, He-shi Liu, Rui Chang and Meng-xiong Wu for their important contributions.

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Authors and Affiliations

  1. Department of Radiology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, No. 197, Ruijin 2nd, Road, Shanghai, 200025, China

    Li-fang Pang, Huan Zhang, Wen-jie Yang, Hua Xiao, Yu-lian Bu, Zi-lai Pan, Ke-min Chen & Fu-hua Yan

  2. GE Health Care China, Shanghai, China

    Wei Lu

  3. Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Wei-qing Xu

  4. Department of Cardiology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

    Ying Chen & Yan Liu

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  1. Li-fang Pang
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  2. Huan Zhang
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Corresponding author

Correspondence to Huan Zhang.

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Pang, Lf., Zhang, H., Lu, W. et al. Spectral CT imaging of myocardial infarction: preliminary animal experience. Eur Radiol 23, 133–138 (2013). https://doi.org/10.1007/s00330-012-2560-9

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  • DOI: https://doi.org/10.1007/s00330-012-2560-9

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